Metallo-supramolecular nanofibers based on type-I photosensitizer for synergistic antibacterial therapy  

作　　者：Shibo Lyu Lukun Li Jingdong Gao Dapeng Liu Fengling Song 

机构地区：[1]Institute of Frontier Chemistry,School of Chemistry and Chemical Engineering,Shandong University,Qingdao,China [2]Department of Chemistry,National University of Singapore,Singapore,Singapore [3]School of Life Sciences,Shandong University,Qingdao,Shandong,China

出　　处：《Smart Molecules》2024年第4期215-223,共9页智能分子(英文)

基　　金：supported financially by the National Key Research and Development Program of China(2023YFC 3403000);the National Natural Science Foundation of China(22378231);the Guangdong Basic and Applied Basic Research Foundation(2024A1515012493).

摘　　要：Photodynamic therapy(PDT)has shown great merits in treating microbial in-fections due to its absence of bacterial resistance.However,the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic effi-ciency of traditional type-II PDT,which is highly dependent on oxygen.Here type-I photosensitizer BTZ_(n)-Py(n=8,20)coordinates with chemical antibacterial agent Agþto fabricate metallo-supramolecular nanofibers.Under light irradiation,the formed nanofibers could not only generate type-Ⅱ reactive oxygen species(ROS),1O2,but also produce type-I ROS O2^(•-)which addressed the hypoxic issues within infected tissues.Moreover,the acid-and photo-active Agþrelease from the nano-fibers endowed the metallo-supramolecular nanofibers with controlled release characteristic,which showed good biocompatibility to normal tissues.Owing to controlled Agþrelease and photoinduced type-I ROS,the in vitro and in vivo ex-periments confirmed the significantly synergistic antibacterial performance of the metallo-supramolecular fibers against both Gram-positive and Gram-negative bacteria.

关 键 词：antibacterial therapy metallo-supramolecular type-I photodynamic therapy 

分 类 号：TB3[一般工业技术—材料科学与工程]