Exploring methodological frontiers in laminar fMRI  

作　　者：Yuhui Chai Ru-Yuan Zhang 

机构地区：[1]Beckman Institute for Advanced Science and Technology,University of Illinois at Urbana-Champaign,Urbana 61801,Illinois,USA [2]Brain Health Institute,National Center for Mental Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine and School of Psychology,Shanghai 200030,the People Republic of China

出　　处：《Psychoradiology》2024年第1期135-143,共9页精神影像学(英文)

基　　金：supported by the National Key R&D Program of China(2023YFF1204200);the National Natural Science Foundation of China(32441102 and 32100901)to R-Y.Zhang;the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health(R03EB034324)to Y.Chai.

摘　　要：This review examines the methodological challenges and advancements in laminar functional magnetic resonance imaging(fMRI).With the advent of ultra-high-field MRI scanners,laminar fMRI has become pivotal in elucidating the intricate micro-architectures and functionalities of the human brain at a mesoscopic scale.Despite its profound potential,laminar fMRI faces significant challenges such as signal loss at high spatial resolution,limited specificity to laminar signatures,complex layer-specific analysis,the necessity for precise anatomical alignment,and prolonged acquisition times.This review discusses current methodologies,highlights typical challenges in laminar fMRI research,introduces innovative sequence and analysis methods,and outlines potential solutions for overcoming existing technical barriers.It aims to provide a technical overview of the field's current state,emphasizing both the impact of existing hurdles and the advancements that shape future prospects.

关 键 词：Laminar fMRI cortical layer cortical depth high-resolution fMRI 

分 类 号：R44[医药卫生—诊断学]