基于从肝论治的气络调节探讨肠道菌群-胆汁酸轴改善2型糖尿病胰岛素抵抗  

To Explore the Effect of Gut Microbiota-Bile Acid Axis on Insulin Resistance in Type 2 Diabetes Mellitus Based on Liver-Oriented Therapy with Qi Colligation Regulation

作　　者：王宇 宋佳媛 王丽 张乃文 朴春丽 WANG Yu;SONG Jiayuan;Wang Li;ZHANG Naiwen;PIAO Chunli(School of Chinese Medicine,Changchun University of Chinese Medicine,Changchun 130000,China;College of Integrative Medicine,Changchun University of Chinese Medicine,Changchun 130000,China;Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine(Futian),Shenzhen 518000,China)

机构地区：[1]长春中医药大学中医学院,长春130000 [2]长春中医药大学中西医结合学院,长春130000 [3]广州中医药大学深圳医院(福田),深圳518000

出　　处：《世界科学技术-中医药现代化》2024年第11期2914-2920,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会面上项目(82374380):基于胆汁酸介导的TGR5/GLP-1环路探究解毒通络调肝方调控肠肝轴改善T2DM-IR作用机制,负责人:朴春丽;深圳市科技创新委员会科技计划项目(JCYJ20220531091409022):解毒通络调肝方通过FMO3-FXR通路调控肠肝轴改善T2DM-IR作用机制的研究,负责人:朴春丽;深圳市福田区卫生健康系统科研项目(FTWS2022036):基于肠肝轴探讨解毒通络调肝方对T2DM合并NAFLD患者胆固醇反转运的临床观察,负责人:王丽。

摘　　要：研究发现,肠道菌群和胆汁酸代谢在2型糖尿病胰岛素抵抗(Type 2 diabetes mellitus-insulin resistance,T2DM-IR)的发生和发展中发挥了重要作用。近年来研究表明,肝失疏泄导致的肝气络形气转化失常是T2DM-IR的病机关键,且与肠道菌群和胆汁酸代谢失调关系密切。本文深入探讨了肠道菌群与胆汁酸代谢在中医从肝论治的气络调节中的重要作用,揭示其对促进胰岛素敏感性提升以及能量代谢平衡的积极影响,为临床治疗2型糖尿病提供参考和借鉴价值。Studies have found that gut microbiota and bile acids metabolism play an important role in the occurrence and development of type 2 diabetes mellitus and insulin resistance(T2DM-IR).Recent studies have shown that the abnormal transformation of qi and Liver-qi collaterals caused by liver dysfunction is the key to the pathogenesis of T2DM-IR,which is closely related to intestinal flora and bile acid metabolism disorders.This article delves into the crucial role of intestinal microbiota and bile acid metabolism in regulating qi and collaterals within traditional Chinese medicine treatment from a hepatic perspective.It unveils its favorable impact on enhancing insulin sensitivity and achieving balance in energy metabolism,thereby offering valuable references for clinical management of T2DM.

关 键 词：肠道菌群失调 胰岛素抵抗 2型糖尿病 胆汁酸代谢 气络学说 

分 类 号：R587.1[医药卫生—内分泌]