Rice E3 ubiquitin ligases: From key modulators of host immunity to potential breeding applications  

作　　者：Yuqing Yan Hui Wang Yan Bi Fengming Song 

机构地区：[1]National Key Laboratory for Rice Biology and Breeding,Institute of Biotechnology,Zhejiang University,Hangzhou 310058,China [2]Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests,Institute of Biotechnology,Zhejiang University,Hangzhou 310058,China [3]Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province,Institute of Biotechnology,Zhejiang University,Hangzhou 310058,China

出　　处：《Plant Communications》2024年第12期53-72,共20页植物通讯(英文)

基　　金：National Natural Science Foundation of China(no.32072403 and no.31871945).

摘　　要：To combat pathogen attacks, plants have developed a highly advanced immune system, which requires tight regulation to initiate robust defense responses while simultaneously preventing autoimmunity. The ubiquitin-proteasome system (UPS), which is responsible for degrading excess or misfolded proteins, has vital roles in ensuring strong and effective immune responses. E3 ligases, as key UPS components, play extensively documented roles in rice immunity by modulating the ubiquitination and degradation of downstream substrates involved in various immune signaling pathways. Here, we summarize the crucial roles of rice E3 ligases in both pathogen/microbe/damage-associated molecular pattern-triggered immunity and effector-triggered immunity, highlight the molecular mechanisms by which E3 ligases function in rice immune signaling, and emphasize the functions of E3 ligases as targets of pathogen effectors for pathogenesis. We also discuss potential strategies for application of immunity-associated E3 ligases in breeding of disease-resistant rice varieties without growth penalty. This review provides a comprehensive and updated understanding of the sophisticated and interconnected regulatory functions of E3 ligases in rice immunity and in balancing immunity with growth and development.

关 键 词：rice immunity E3 ubiquitin ligase immune signaling pathogen effectors crop breeding 

分 类 号：S435.11[农业科学—农业昆虫与害虫防治]