Self-adaptive epidermal blood flow sensor forhigh-flux vascular access monitoring of hemodialysis patients  

作　　者：Yuqi Tian Kai Yang Yicong Wang Jie Wang Andrea S.Carlini Zhinan Zhang Yujun Deng Jinyun Tan Linfa Peng Bo Yu Zhongqin Lin 

机构地区：[1]Shanghai Key Laboratory of Digital Manufacture for Thin-Walled Structures,Shanghai Jiao Tong University,Shanghai,PR China [2]State Key Laboratory of Mechanical System and Vibration,Shanghai Jiao Tong University,Shanghai,PR China [3]Department of Vascular Surgery,Shanghai Pudong Hospital,Fudan University Pudong Medical Center,Shanghai,PR China [4]Department of Chemistry and Biochemistry,Department of Biomolecular Science and Engineering,Center for Polymers and Organic Solids,University of California at Santa Barbara,Santa Barbara,CA,USA [5]Vascular Surgery Department,Huashan Hospital,Fudan University,Shanghai,PR China [6]Fudan Zhangjiang Institute,Shanghai,PR China [7]Shanghai Key Laboratory of Vascular Lesions Regulation and Remodelling,Shanghai,PR China

出　　处：《npj Flexible Electronics》2024年第1期253-266,共14页npj-柔性电子(英文)

基　　金：supported by the Natural Science Foundation of Shanghai(23ZR1428600);National Natural Science Foundation of China(52371249,L232400044);State Key Laboratory of Mechanical System and Vibration(Grant No.MSVZD202110);the University of California and a UCSB Faculty Research Grant.

摘　　要：Well-functioning vascular access(VA)is essential for hemodialysis treatment in patients with endstage renal disease(ESRD).However,continuous and accurate monitoring of blood flow to assess high-flux VA during hospitalization or at home is not feasible for either clinical instruments or wearable sensors.Here,we report the design and preclinical validation of a high-precision,long-term,epidermal blood flow sensor that self-adapts to unavoidable sensor-mounting deviations on the skin and is compatible with individual tissue differences.Specifically,the technology is based on thermal dissipation of the skin,and improves the signal-to-error ratio surpassing 4 timeswhenmeasuring highflux blood(100–600 mL/min).In preclinical validation,the sensor is compared with the Doppler ultrasound and demonstrate a blood flow resolution of 10–50 mL/min.Furthermore,it is highlyintegrated and wearable,measuring 36×50mm^(2).The sensor paves the way for accurate,convenient,high-flux blood monitoring,offering significant potential to extend the lives of patients with ESRD.

关 键 词：flow INDIVIDUAL offering 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]