Flexible adaptive sensing tonometry for medical-grade multi-parametric hemodynamic monitoring  

作　　者：Mengkang Deng Chentao Du Jiayuan Fang Changshun Xu Chenhui Guo Jiantao Huang Kang Li Lei Chen Yuan-Ting Zhang Yu Chang Tingrui Pan 

机构地区：[1]School of Biomedical Engineering,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,PR China [2]Suzhou Institute for Advanced Research,University of Science and Technology of China,Suzhou,PR China [3]Department of Biomedical Engineering,City University of Hong Kong,Hong Kong SAR,PR China [4]West China Biomedical Big Data Center,West China Hospital,Sichuan University,Chengdu,PR China [5]Department of Neurology,West China Hospital,Sichuan University,Chengdu,PR China [6]Hong Kong Institute of Medical Engineering,Chinese University of Hong Kong(CUHK),Hong Kong SAR,PR China [7]Department of Electronic Engineering,Chinese University of Hong Kong(CUHK),Hong Kong SAR,PR China [8]Bionic Sensing and Intelligence Center(BSIC),Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,PR China [9]Department of Precision Machinery and Precision Instrumentation,University of Science and Technology of China,Hefei,PR China

出　　处：《npj Flexible Electronics》2024年第1期437-452,共16页npj-柔性电子(英文)

基　　金：supported by the following funding,National Key R&D Program of China(2022YFB3805804);Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao(51929501);National Natural Science Foundation of China(62001461);Students'Innovation and Entrepreneurship Foundation of USTC,Natural Science Foundation of Shenzhen(JCYJ20220818101207017);Innovation&Entrepreneurship leader program of Suzhou(ZXL2023153).

摘　　要：Continuous hemodynamic monitoring in a wearable means can play a crucial role in managing hypertension and preventing catastrophic cardiovascular events.In this study,we have described the fully wearable tonometric device,referred to as flexible adaptive sensing tonometry(FAST),which is capable of continuous and accurate monitoring of hemodynamic parameters within the medical-grade precision.In particular,the FAST system integrates a 1×8 unit array of highly sensitive and highly flexible iontronic sensing(FITS)with 1mm spatial resolution and a closed-loop motion system.The flexible tonometric architecture has been used to determine the radial arterial position with high sensitivity and high conformability,which simplifies the biaxial searching process of the traditional applanation tonometry into a highly efficient uniaxial applanation while keeping the medical-precision assessments.Importantly,a self-calibration algorithm can be automatically implemented during the applanation process,from which the intra-arterial blood pressure wave can be continuously predicted within the medical-grade precision,and subsequently,multi-parametric hemodynamic analysis can be performed in real-time.Experimental validations on health volunteers have demonstrated that the FAST measurements are all within the required accuracy of the clinical standards for continuous pulse wave assessments,blood pressure monitoring as well as other key hemodynamic parameter evaluations.Therefore,the FAST system,by integrating the flexible iontronic sensing array,provides a real-time,medical-grade hemodynamicmonitoring solution in a continuously wearable manner,from which remote patient-centered monitoring can be delivered with both medical precision and convenience.

关 键 词：PARAMETRIC continuously monitoring 

分 类 号：TP2[自动化与计算机技术—检测技术与自动化装置]