Uniaxial extending neural probes for bleeding-absent implantation  

作　　者：Xueyang Ren Wen Bai Shisheng Chen Yuehui Yuan Xiaodong Shao Xuefei Zhu LiWang Qin Jiang Benhui Hu 

机构地区：[1]School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing,China [2]School of Biological Science and Medical Engineering,Southeast University,Nanjing,China [3]Affiliated Eye Hospital of Nanjing Medical University,Nanjing,China [4]School of Electronic Science and Engineering,Southeast University,Nanjing,China [5]PKU-Nanjing Joint Institute of Translational Medicine,Nanjing,China

出　　处：《npj Flexible Electronics》2024年第1期545-556,共12页npj-柔性电子(英文)

基　　金：supported by the National Natural Science Foundation of China(81971701);the Natural Science Foundation of Jiangsu Province(BK20201352);the NanjingMedical University Introduced Talents Scientific Research Start-up Fund(NMUR20190003);the STI2030-Major Projects(2021ZD0202205).

摘　　要：Implantable neural probes,essential for brain electrophysiological research,have advanced with ultraflexible designs to mitigate immune responses and postoperativecomplications.Strategies of shuttleassisted implantation and temporary stiffening address issues in penetrating these probes into the target region,avoiding undesired bending.However,the risk of intraoperative bleeding remains due to these implants’necessary rigidity during insertion.Here,we describe a neural probe with mechanical compliance accompanying self-implantation along the principal axis in the absence of bleeding.Crucial to the behavior is its anisotropic relaxation,which is dominated by the cross-sectional in-plane deformation inhibition due to interchain interactions between the parallel backbones in the globally aligned polymer system.We observed the ensured upright insertion of the probe into the brain while avoiding angiorrhexis with a two-photon microscope and a high-speed camera.The probes permit electrophysiological studies with minimal foreign body responses and imageological compatibility,underscoring their clinical potential.

关 键 词：deformation IMPLANTATION NEURAL 

分 类 号：TG1[金属学及工艺—金属学]