中国无偿献血人群抗-HEV反应性率Meta分析  

Anti-HEV antibody reactivity rate in voluntary blood donors in China:a Meta-analysis

作　　者：徐妞妞 焦占营 XU Niuniu;JIAO Zhanying(Wuhan Blood Center,Wuhan 430030,China;Department of Radiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]武汉血液中心,湖北武汉430030 [2]华中科技大学同济医学院附属同济医院放射科,湖北武汉430030

出　　处：《中国输血杂志》2025年第1期26-37,共12页Chinese Journal of Blood Transfusion

摘　　要：目的通过Meta分析了解中国无偿献血人群抗-HEV反应性率与不同年龄段的关系。方法检索中国知网(CNKI)、PubMed、以及万方医学数据库中所有关于中国不同年龄段无偿献血人群抗-HEV IgG反应性率和抗-HEV IgM反应性率的文献,检索时间为2007年1月1日—2023年12月31日。对纳入文献按年龄统一分组后选择风险差(RD)作为效应量,利用Review Manager 5.3软件进行Meta分析。结果共纳入17篇文献,其中抗-HEV IgG 16篇,抗-HEV IgM 15篇。按年龄分段方式的不同,分为2个组。A组的年龄段划分方式为≤20岁、21~30岁、31~40岁、41~50岁和>50岁;B组的年龄段划分方式为18~25岁、26~35岁、36~45岁和≥46岁。Meta分析合并结果显示:A组抗-HEV IgG反应性率RD值为22.92%[95%CI(19.02%,26.82%)],抗-HEV IgM反应性率RD值为0.67%[95%CI(0.51%,0.82%)];B组抗-HEV IgG反应性率RD值为33.03%[95%CI(28.01%,38.05%)],抗-HEV IgM反应性率RD值为1.13%[95%CI(1.05%,1.21%)]。亚组分析结果显示:在A、B 2组中,无偿献血人群中抗-HEV IgG反应性率都伴随着年龄的增长而增加。在A组中,未发现无偿献血人群中抗-HEV IgM反应性率随着年龄的增长而增加,在B组中,抗-HEV IgM反应性率随着年龄的增长而增加,进一步分析发现,A、B 2组中,在抗-HEV IgM反应性率>1%的地区,抗-HEV IgM反应性率都有随着年龄增长而增加的趋势。结论无偿献血人群中抗-HEV IgG反应性率和抗-HEV IgM反应性率都随着年龄增长而增加。Objective To explore the relationship between anti-HEV antibody reactivity rate and different age groups in Chinese voluntary blood donors by Meta-analysis.Methods Literatures on anti-HEV IgG reactivity rate and anti-HEV IgM reactivity rate of voluntary blood donors in different age groups in China were searched from China National Knowledge Infrastructure(CNKI),PubMed and Wanfang Medicine database,with a search time from January 1,2007 to December 31,2023.Risk difference(RD)was selected as the effect size after grouping the included literature according to age,and metaanalysis was performed using Review Manager 5.3 software.Results A total of 17 articles were included,among which 16 were about anti-HEV IgG and 15 about anti-HEV IgM.Based on different age grouping methods,they were divided into two groups.The age groups of group A were divided into≤20 years old,21-30 years old,31-40 years old,41-50 years old and>50 years old.The age groups of group B were divided into 18-25 years old,26-35 years old,36-45 years old,and≥46 years old.The pooled results of Meta-analysis showed that the RD value of anti-HEV IgG reactivity rate in group A was 22.92%[95%CI(19.02%,26.82%)],and the RD value of anti-HEV IgM reactivity rate was 0.67%[95%CI(0.51%,0.82%)].The RD value of anti-HEV IgG reactivity rate in group B was 33.03%[95%CI(28.01%,38.05%)],and the RD value of anti-HEV IgM reactivity rate was 1.13%[95%CI(1.05%,1.21%)].The results of subgroup analysis showed that in both group A and B,the anti-HEV IgG reactivity rate in voluntary blood donors increased with age.In group A,no increase in the reactivity rate of anti-HEV IgM with age was found in voluntary blood donors.In group B,the anti-HEV IgM reactivity rate increased with age.Further analysis showed that in the two groups of A and B,the anti-HEV IgM reactivity rate increased with age in areas where the anti-HEV IgM reactivity rate was greater than 1%.Conclusion The anti-HEV IgG reactivity rate and anti-HEV IgM reactivity rate in voluntary blood donors increased with a

关 键 词：戊型肝炎病毒 血液筛查 META分析 经血传播 输血安全 

分 类 号：R457.1[医药卫生—治疗学] R373.2[医药卫生—临床医学] R446