人工胶体血浆代用品的分类及其临床研究  

Classification and advances in clinical research of artificial colloidal plasma substitutes

作　　者：畅正阳 李明[1] 高建朋 张静[1] 吕华[2] 张里程[1] CHANG Zhengyang;LI Ming;GAO Jianpeng;ZHANG Jing;LYU Hua;ZHANG Licheng(Orthopedic Department of the Fourth Medical Center of the People′s Liberation Army General Hospital,Beijing 100048 China;School of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China)

机构地区：[1]解放军总医院第四医学中心骨科医学部,北京100048 [2]北京大学化学与分子工程学院,北京100871

出　　处：《中国输血杂志》2025年第1期136-141,共6页Chinese Journal of Blood Transfusion

基　　金：军队基础加强计划重点基础研究项目子课题(2020-JCJQ-ZD-264-*);解放军总医院青年自主创新科学基金成长项目(22QNCZ030);解放军总医院“3+1”创新人才建设工程第一批青年科技英才培育对象(20230419);国家重点研发计划(2022YFC2504300)。

摘　　要：因大出血、骨折、严重感染、大面积烧伤以及肿瘤等原因导致血容量减少的患者数量呈上升趋势,传统的血液制品已难以满足日益增长的临床需求。因此,血浆代用品在液体复苏中变得尤为重要,尤其是人工胶体合成液,其具有持续的扩容时间和良好的扩容效果,能够显著改善患者的循环状况。本文旨在对人工胶体血浆代用品的分类及其在临床上的研究进展进行综述,以期为医学界提供更为严谨、专业和标准化的参考方案。The number of patients with reduced blood volume due to haemorrhage,fractures,severe infections,extensive burns and tumours is increasing,and traditional blood products are no longer able to meet the increasing clinical demand.Therefore,plasma substitutes have become particularly important in fluid resuscitation,especially artificial colloidal solutions,which have a sustained volume expansion time and a good volume expansion effect,and can significantly improve the circulatory status of patients.This article aims to review the classification of artificial colloidal plasma substitutes and their research progress in clinical practice,in order provide a more rigorous,professional and standardized reference for medicine.

关 键 词：休克 血浆代用品 液体复苏 胶体液 内皮糖萼 

分 类 号：R605.971[医药卫生—急诊医学] R457.14[医药卫生—外科学]