Exposure to Multiple Endocrine-Disrupting Chemicals and Associations with Female Infertility:A Case-Control Study  

作　　者：Xianping Wei Na Zhang Qingqing Zhu Yu Hu Xin Wang Xueyu Weng Chunyang Liao Guibin Jiang 

机构地区：[1]State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China [2]Department of Ultrasound,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China [3]College of Resources and Environment,University of Chinese Academy of Sciences,Beijing 100049,China [4]Institute of Environment and Health,Hangzhou Institute for Advanced Study,UCAS,Hangzhou,Zhejiang 310024,China [5]Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances,School of Environment and Health,Jianghan University,Wuhan,Hubei 430056,China

出　　处：《Environment & Health》2024年第12期902-911,共10页环境与健康(英文)

基　　金：financially supported by the National Natural Science Foundation of China(22225605,22193051,and 22006103);the National Key Research and Development Program of China(2023YFC3706600 and 2022YFC2703303);the K.C.Wong Education Foundation of China(GJTD-2020-03);the Professor station of China Agricultural University at Xinzhou Center for Disease Control and Prevention.

摘　　要：Parabens(PBs)and their metabolites(MBs),triclocarban(TCC),triclosan(TCS),bisphenols(BPs),benzophenones(BzPs),and phthalate metabolites(mPAEs)are typical endocrine-disrupting chemicals(EDCs)used in industrial production and daily life.Studies have suggested that these EDCs affect the reproductive system and may cause infertility;however,epidemiological evidence linking EDC exposure to infertility is still lacking.Herein,a total of 302 serum samples from women of reproductive age were collected,and six categories of typical EDCs were analyzed.The results revealed that EDCs are ubiquitous in female serum.The geometric mean(GM)concentrations of∑PBs,∑MBs,∑(TCS+TCC),∑BPs,∑BzPs,and∑mPAEs were 3.36,297,3.87,4.39,0.257,and 4.56 ng/mL,respectively.The serum concentrations of∑PBs,∑MBs,∑(TCS+TCC),and∑mPAEs from infertile women(GM:4.16,397,4.01,and 7.33,respectively)were higher than those from fertile women(2.45,192,3.65,and 2.27,respectively)(p<0.05).The results of binary logistic regression and random forest suggest that mPAEs,such as mBP/miBP and mEHP,may contribute to infertility.This study provides insight into the relationship between the EDC exposure and reproductive outcomes.

关 键 词：Endocrine-disrupting chemicals Human exposure Female infertility SERUM ASSOCIATION 

分 类 号：X70[环境科学与工程—环境工程]