Observed Effects on Very Early Pregnancy Linked to Ambient PM_(2.5) Exposure in China among Women Undergoing In Vitro FertilizationEmbryo Transfer  

作　　者：Changxin Lan Yichun Guan Haining Luo Xiaoling Ma Yihua Yang Hongchu Bao Cuifang Hao Xiaojin He Han Zhang Ning Gao Weinan Lin Mengyuan Ren Tianxiang Wu Chao Wang Xiaoqing Ni Chunyan Shen Jianrui Zhang Junfang Ma Rui Zhang Yin Bi Lili Zhuang Ruichao Miao Ziyi Song Tong An Zhengteng Liu Bo Pan Mingliang Fang Jing Liu Zhipeng Bai Fangang Meng Yuanchen Chen Xiaoxia Lu Yuming Guo Yunxia Cao Qun Lu Bin Wang 

机构地区：[1]Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China [2]Institute of Reproductive and Child Health,Key Laboratory of Reproductive Health,National Health and Family Planning Commission of the People’s Republic of China,Beijing 100191,China [3]Department of Reproductive Medicine,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China [4]Reproductive Medicine Center,Tianjin Central Hospital of Gynecology Obstetrics,Maternity Hospital of Nankai University,Tianjin 300052,China [5]The First Hospital of Lanzhou University,the First Clinical Medical School of Lanzhou University,Lanzhou 730000,China [6]Guangxi Reproductive Medical Center,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China [7]Reproductive Medicine Centre,Yuhuangding Hospital of Yantai,Affiliated Hospital of Qingdao University,Yantai 264000,China [8]Qingdao Women and Children’s Hospital,Affiliated Hospital of Qingdao University,Qingdao 266555,China [9]Reproductive Medicine Center,Department of Obstetrics and Gynecology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [10]Department of Obstetrics and Gynecology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China [11]Engineering Research Center of Biopreservation and Artificial Organs,Ministry of Education,Hefei 230022,China [12]Medical Center for Human Reproduction,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020,China [13]Yunnan Provincial Key Lab of Soil Carbon Sequestration and Pollution Control,Faculty of Environmental Science and Engineering,Kunming University of Science and Technology,Kunming 650500,China [14]MOE Key Laboratory of Environmental Remediation and Ecosystem Health,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou 310058,China [15]State Key Laboratory of Environmental Criteria and Risk Assessment,Chinese Research Academy of Environmental Sciences,Beijing 100012,Ch

出　　处：《Environment & Health》2024年第12期918-928,共11页环境与健康(英文)

基　　金：National Key Research&Development Program of Ministry of Science and Technology of China,No.2023YFC3708305(ZPB),2022YFE0134900(JL),and 2022YFC2704404(QL);National Natural Science Foundation of China,No.42077390(BW),41771527(BW);Yunnan Major Scientific and Technological Projects,No.202202AG050019(BP).

摘　　要：The adverse effect of ambient PM_(2.5) exposure on very early pregnancy(VEP)remains controversial among epidemiological studies but is supported by toxicological evidence.We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM_(2.5) exposure on the VEP using the in vitro fertilization and embryo transfer platform and high-resolution PM_(2.5) data in China.We first investigated the association between PM_(2.5) exposure 1 week before and 1 week after the embryo transfer date and VEP.The average PM_(2.5) concentrations of the 2 weeks were approximately 47μg/m^(3).The pooled results revealed a negative association between women’s accumulated PM_(2.5) exposure during the 2 weeks near the day of embryo transfer and success odds of VEP with the relative risk of 0.999(95%CI:0.997-0.999)at each increase of 10μg/m3.The women with the fresh cycle or one transplanted embryo were considered as a vulnerable population.Furthermore,seven periods for the fresh cycle and five periods for the frozen cycle from 85 days before oocyte retrieval to the day of gestational sac detection by ultrasound detection were defined.For these exposure periods,no association between the average PM_(2.5) exposure and VEP risk was identified.Our study provided large-scale population evidence for the association between PM_(2.5) exposure near embryo transfer day and VEP and identified vulnerable populations among women undergoing in vitro fertilization-embryo transfer.

关 键 词：Fine particulate matter Very early pregnancy IVF-ET Biochemical pregnancy Clinical pregnancy 

分 类 号：X51[环境科学与工程—环境工程]