妊娠期高血压患者血清miR-488、miR-184表达与子痫前期发生的关系  

Relationship between the expression of serum miR-488 and miR-184 and the occurrence of preeclampsia in patients with gestational hypertension

作　　者：王丹丹 邓梦烨 沈红[1] 王进进[1] WANG Dandan;DENG Mengye;SHEN Hong;WANG Jinjin(Department of Obstetrics,Jiangyin Traditional Chinese Medicine Hospital,Jiangyin,Jiangsu 214400,China)

机构地区：[1]江苏省江阴市中医院产科,江苏江阴214400

出　　处：《国际检验医学杂志》2025年第3期276-280,286,共6页International Journal of Laboratory Medicine

基　　金：江苏省中医药科技发展计划项目(YB2020045)。

摘　　要：目的探讨妊娠期高血压患者血清微小核糖核酸(miR)-488、miR-184表达与子痫前期发生的关系。方法选取2022年6月至2023年3月该院收治的妊娠期高血压患者128例,根据是否发展为子痫前期分为单纯妊娠期高血压组55例和合并子痫前期组73例。另选取同期该院46例健康妊娠孕妇为对照组。采用实时荧光定量聚合酶链反应检测各组miR-488、miR-184表达,以及多因素Logistic回归分析妊娠期高血压患者子痫前期发生的影响因素。受试者工作特征(ROC)曲线分析各影响因素对妊娠期高血压患者子痫前期发生的预测价值及Pearson相关性分析血清miR-488、miR-184与胎盘生长因子的相关性。结果与对照组比较,单纯妊娠期高血压组、合并子痫前期组血清miR-488、miR-184表达升高,差异有统计学意义(P<0.05)。与轻度子痫前期组比较,重度子痫前期组血清miR-488、miR-184表达升高,差异有统计学意义(P<0.05)。合并子痫前期组孕产次、收缩压、舒张压、尿蛋白定量及胎盘生长因子水平与单纯妊娠期高血压组比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,孕产次、收缩压、舒张压、尿蛋白定量、miR-488及miR-184均为妊娠期高血压患者子痫前期发生的危险因素(P<0.05),胎盘生长因子为妊娠期高血压患者子痫前期发生的保护因素(P<0.05)。ROC曲线分析结果显示,miR-488+miR-184预测效能显著优于血清miR-488(Z=2.530,P=0.011)、miR-184(Z=2.437,P=0.015)单独预测。血清miR-488、miR-184与胎盘生长因子呈负相关(r=-4.361、-4.288,P<0.05)。结论血清miR-488、miR-184对妊娠期高血压患者子痫前期发生具有预测价值。Objective To investigate the relationship between the expression of serum microRNA(miR)-488 and miR-184 and the occurrence of preeclampsia in patients with gestational hypertension.Methods A total of 128 patients with gestational hypertension admitted to a hospital from June 2022 to March 2023 were selected and divided into the simple gestational hypertension group(55 cases)and the combined with preeclampsia group(73 cases)according to whether they developed preeclampsia.Another 46 healthy pregnant women in the same period were selected as the control group.Real-time fluorescence quantitative polymerase chain reaction was used to detect miR-488 and miR-184 expression in each group,and multiple Logistic regression was used to analyze the influencing factors of the occurrence of preeclampsia in patients with gestational hypertension.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of each influencing factor in the occurrence of preeclampsia in patients with gestational hypertension,and Pearson correlation was used to analyze the correlation between serum miR-488,miR-184 and placental growth factor.Results Compared with the control group,the expressions of serum miR-488 and miR-184 were increased in the simple pregnancy hypertension group and the combined with preeclampsia group,and the differences were statistically significant(P<0.05).Compared with mild preeclampsia group,serum miR-488 and miR-184 expressions were increased in severe preeclampsia group,and the difference was statistically significant(P<0.05).There were significant differences in gravida and parity,systolic blood pressure,diastolic blood pressure,urinary protein quantity and placental growth factor levels between the combined with preeclampsia group and the simple pregnancy hypertension group(P<0.05).Multiple Logistic regression analysis showed that gravida and parity,systolic blood pressure,diastolic blood pressure,urinary protein quantity,miR-488 and miR-184 were risk factors for preeclampsia in patients with g

关 键 词：妊娠期高血压 子痫前期 微小核糖核酸-488 微小核糖核酸-184 

分 类 号：R714.24[医药卫生—妇产科学]