隐匿性乙型肝炎病毒感染相关的血清学标志物的研究进展  

Advances in serological markers associated with occult hepatitis B virus infection

作　　者：彭兰新(综述) 向瑜(审校)[1] PENG Lanxin;XIANG Yu(Department of Clinical Laboratory,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院检验科,重庆400016

出　　处：《国际检验医学杂志》2025年第3期340-344,共5页International Journal of Laboratory Medicine

基　　金：重庆市自然科学基金面上项目(CSTB2023NSCQMSX0376)。

摘　　要：随着乙型肝炎病毒(HBV)检测技术的进步,发现部分患者体内的乙型肝炎病毒表面抗原阴性,但肝脏或血清中HBV脱氧核糖核酸呈阳性,这种特殊感染类型称为隐匿性乙型肝炎病毒感染(OBI)。OBI发病机制主要与病毒突变、宿主免疫反应、表观遗传学、与丙型肝炎病毒共感染等相关。OBI临床风险主要包括HBV的传播、在机体免疫力下降时发生HBV再激活、肝癌发生等。由于OBI独特的血清模式、临床表现、部分检测指标的方法学受限等因素,导致OBI检出率比较低。因此,急需寻找新型的血清学标志物来提高OBI的检出率,降低HBV传播的风险。该文主要围绕OBI相关的血清学标志物的研究进展进行综述。With the advancement of hepatitis B virus(HBV)testing technology,it has been found that some patients are negative for hepatitis B virus surface antigen but positive for HBV deoxyribonucleic acid in liver or serum,and this particular type of infection is known as occult hepatitis B virus infection(OBI).The pathogenesis of OBI is mainly related to viral mutations,host immune response,epigenetics,and co-infection with hepatitis C virus.The clinical risks of OBI mainly include the spread of HBV,HBV reactivation in the presence of decreased body immunity,and hepatocarcinogenesis.The detection rate of OBI is relatively low due to the unique serum pattern,clinical manifestations and methodological limitations of some detection indicators of OBI.Therefore,there is an urgent need to find novel serologic markers to improve the detection rate of OBI and reduce the risk of HBV transmission.This article mainly focuses on the review of the research progress of serological markers related to OBI.

关 键 词：隐匿性乙型肝炎病毒感染 血清学标志物 发病机制 

分 类 号：R512.62[医药卫生—内科学]