Modular,Scalable Total Synthesis of Neopetromin  

作　　者：Hiroshige Ogawa Yuuya Nagata Hugh Nakamura 

机构地区：[1]Department of Chemistry,The Hong Kong University of Science and Technology,Clear Water Bay,999077 Hong Kong SAR,China [2]WPI Institute for Chemical Reaction Design and Discovery(WPl-ICReDD),HokkaidoUniversity,Sapporo 001-0021,Japan

出　　处：《Chinese Journal of Chemistry》2024年第23期3023-3028,共6页中国化学(英文版)

基　　金：Financial support for this work was provided by a grant from the RGC of the Hong Kong SAR,China(ECS,HKUST 26302024);start-up funds from HKUST(Project No.R9820)to H.N;This work was partly supported by JSPS KAKENHI Grant Number JP23H03810,JST-ERATO(JPMJER1903);the Institute for Chemical Reaction Design and Discovery(ICReDD),which was established by the World Premier International Research Initiative(WPI),MEXT,Japan(Y.N.);The computation was partly performed using Research Center for Computational Science,Okazaki,Japan(Project:23-IMS-C119,Y.N.).

摘　　要：The first total synthesis of neopetromin,featuring the highly strained Tyr C-6-to-Trp N-1’linkage,is hereby reported.This modular synthetic strategy,employing C—H arylation and Larock macrocyclization,offers a novel approach to the synthesis of various RiPPs natural product families.

关 键 词：Total synthesis Natural product Biaryl cyclic peptides RiPPs C-H activation Larock macrocyclization Scalable synthesis 

分 类 号：O62[理学—有机化学]