Formate-Mediated Synthesis ofβ-Hydroxysulfides from Olefins and Thiosulfonates via EDA Complex Strategy under Visible Light Irradiation in Air  

作　　者：Qing Shen Xiaoyan Peng Jiahong Sui Min Peng Xiangwei Liu Hezhong Jiang Rui Tan Min Zhou Jiahong Li 

机构地区：[1]Department of Pharmacy,Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China [2]Schoolof Life Science and Engineering,School of Chemistry,Southwest Jiaotong University,Chengdu,Sichuan 610041,China [3]Chengdu Organic Chemistry Co.,Ltd.,Chinese Academy of Sciences,Chengdu,Sichuan 610041,China

出　　处：《Chinese Journal of Chemistry》2024年第23期3129-3134,共6页中国化学(英文版)

基　　金：National Natural Science Foundation of China(Grant Nos.21901216 and 21871031);the Funds of Sichuan Science and Technology Program(Nos.23NSFSC0862 and 2023NSFSC0104);the Fundamental Research Funds for the Central Universities(No.2682023ZTPY003).

摘　　要：A visible-light-induced and efficient one-pot synthesis ofβ-hydroxysulfides from olefins,thiosulfonates and HCOOCs using an EDA complex strategy under air atmosphere at room temperature has been disclosed.A plausible radical involved mechanism is proposed.During the reaction process,formates play a crucial role:first,as donors in the EDA complex;second,as providers of the hydrogen source;and third,by generating CO_(2)^(•–)to reduce peroxide intermediates,leading to the formation ofβ-hydroxysulfides.In contrast to the previously reported thiol-oxygen co-oxidation reactions,this simple and sustainable approach features mild reaction conditions,operational simplicity,odorless and excellent functional group tolerance.

关 键 词：β-Hydroxysulfides EDA complex Difunctionalization Thiosulfonates FORMATE Radical Photocatalysis OXYGENATION 

分 类 号：O62[理学—有机化学]