Biomolecule-responsive polymers and their bio-applications  

作　　者：Yuting Xiong Minmin Li Guangyan Qing 

机构地区：[1]State Key Laboratory of Medical Proteomics,National Chromatographic R.&A.Center,CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,People's Republic of China [2]School of Chemistry and Materials Science,East China University of Technology,Nanchang,People's Republic of China

出　　处：《Interdisciplinary Materials》2024年第6期865-896,共32页交叉学科材料(英文)

基　　金：National Key Research and Development Program of China,Grant/Award Number:2022YFC3400800;National Natural Science Foundation of China,Grant/Award Numbers:22004120,22174138,22104013;DICP Innovation Funding,Grant/Award Numbers:I202243,I202229;Dalian Outstanding Young Scientific Talent,Grant/Award Number:2020RJ01;Natural Science Foundation of Jiangxi Province,Grant/Award Numbers:20212BAB213002,20232BAB213049。

摘　　要：Precise recognition and specific interactions between biomolecules are key prerequisites for ensuring the performance of all actives within living organisms.The convergence of biomolecular recognition systems into synthetic materials could endow the materials with high specificity and biological sensitivity;this,in turn,enables precise drug release,monitoring or detection of important biomolecules,and cell manipulation through targeted capture or release of specific biomolecules.Meanwhile,from the perspective of materials science,the application of conventional polymers in practical biological systems poses several challenges,such as low responsiveness and sensitivity,inadequate targetability,insufficient anti-interference capacities,and unsatisfactory biocompatibility.These problems could be partly attributed to the polymers'weak discrimination abilities toward target biomolecules in the presence of interfering substances with high abundance.In particular,the proposition of“precision medicine”project raises higher demands for the design of biomaterials in terms of their precision and targetability.Therefore,there is an urgent demand for the development of new-generation biomaterials with precise recognition and sensitive responsiveness comparable to biomacro-molecules.This promotes a new research direction of biomolecule-responsive polymers and their diverse applications.This review focuses on the origin and construction of biomolecule-responsive polymers,as well as their attractive applications in drug delivery systems,bio-detection,bio-sensing,separation,and enrichment,as well as regulating cell adhesion.

关 键 词：biomolecules bio-sensing drug delivery ENRICHMENT smart polymers 

分 类 号：O63[理学—高分子化学]