Potential mechanisms of Streptococcus suis virulence-related factors in blood-brain barrier disruption  

作　　者：Guanzheng Zhao Luyu Ying Yuqian Shi Yuexin Dong Mengjiao Fu Zhangqi Shen 

机构地区：[1]National Key Laboratory of Veterinary Public Health and Safety,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China

出　　处：《One Health Advances》2024年第1期65-75,共11页全健康进展(英文)

基　　金：supported by the National Natural Science Foundation of China(32225048 and 32141001).

摘　　要：Streptococcus suis(S.suis)has emerged as a prevalent bacterial pathogen within the swine industry,posing a substan-tial zoonotic threat to global public health.As an inhabitant of the upper respiratory tracts of animals,S.suis possesses a sophisticated array of virulence-related factors that enable it to breach cellular barriers and induce multisystem inflammation,notably causing meningitis.This review synthesizes current research findings to provide insights into the complicated virulence-related factors employed by S.suis.Special emphasis is given to factors crucial for pen-etrating the host blood-brain barrier(BBB).By summarizing existing knowledge,this review lays the groundwork for future advanced investigations,paving the way for a deeper understanding of S.suis pathogenesis and potential therapeutic interventions.Specifically,comprehensive explorations to unravel the expression dynamics of these virulence-related factors and elucidate the unique pathogenic mechanisms that operate during host attacks could contribute to clinical treatment strategies and advance innovations in vaccine development.

关 键 词：SWINE RULE SUIS 

分 类 号：S85[农业科学—兽医学]