Efficacy of Qi-Gen powder for immunity enhancement and investigation of its therapeutic mechanisms through gene expression profiling  

作　　者：Xueyan Gao Pingping Wang Shaolin Wang Fenfang Yang Danyang Ma Xiaoqin Xu Tingting Huang Huisheng Xie Zhihui Hao 

机构地区：[1]Chinese Veterinary Medicine Innovation Center,College of Veterinary Medicine,China Agricultural University,Beijing,China [2]National Key Laboratory of Veterinary Public Health and Safety,College of Veterinary Medicine,China Agricultural University,Beijing,China [3]Jiangsu Co‑Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,College of Veterinary Medicine,Yangzhou University,Yangzhou,China [4]Chi University,9650 W Hwy 318,Reddick,FL 32686,USA

出　　处：《One Health Advances》2024年第1期83-94,共12页全健康进展(英文)

基　　金：supported by the Beijing Municipal Science and Technology Commission(grant number:Z191100001619001);Key project at central government level:The ability to establish sustainable use of valuable Chinese medicine resources(grant number:2060302).

摘　　要：Infection with different viruses threatens the health of animals in the livestock and poultry industry.Immunopotentia-tors can increase natural immunity and vaccination efficacy;however,most are expensive chemical and biological compounds with questionable safety.Traditional Chinese medicines(TCMs)such as Yupingfeng(YPF),a well-known immunomodulatory remedy,provide healthy alternatives to such agents.The aim of this study was to examine the therapeutic properties of Qi-Gen powder(QG)and compare them with those of YPF.The immune organ index,cytokine levels,and other indicators were utilized to evaluate the effects of QG in an immunosuppression mouse model.QG was further assessed for its ability to enhance vaccine effectiveness in chickens immunized for Newcastle disease virus(NDV).Potential therapeutic mechanisms and targets of QG were examined in the breast cancer cell line MCF-7 using microarray technology combined with the TCM systems pharmacology database of known targets.Compared with model controls,QG improved immunological function,outperforming YPF in mice.QG also enhanced the immunological response to NDV vaccine in immune organs and increased feed intake of chickens.Further research is needed to validate the link between the PI3K/Akt/GSK-3 pathway and the immune-boosting effects of QG.

关 键 词：Traditional Chinese medicine Immune function Effect Mechanism Gene expression profiling analysis 

分 类 号：O62[理学—有机化学]