Trends in antimicrobial resistance in Enterobacterales isolated from children: data from the China Antimicrobial Surveillance Network (CHINET) from 2015-2021  

作　　者：Fen Pan Chun Wang Yang Yang Yan Guo Demei Zhu Hong Zhang China Antimicrobial Surveillance Network(CHINET)Study Group 

机构地区：[1]Department of Clinical laboratory,Shanghai Children’s Hospital,School of medicine,Shanghai Jiao Tong University,Luding Road 355,Putuo District,Shanghai 200062,China [2]Institute of Pediatric Infection,Immunity,and Critical Care Medicine,Shanghai Jiao Tong University School of Medicine,Shanghai 200062,China [3]Institute of Antibiotics,Huashan Hospital,Fudan University,Key Laboratory of Clinical Pharmacology of Antibiotics,National Health Commission,Shanghai 200040,China [4]不详

出　　处：《One Health Advances》2024年第1期122-130,共9页全健康进展(英文)

基　　金：supported by the China Antimicrobial Surveillance Network(Independent Medical Grants from Pfizer,2020QD049);the China Antimicrobial Surveillance Network(Independent Medical Grants from Pfizer,2018QD100);Shanghai Antimicrobial Surveillance Network(3030231003);development of high sensitivity multipathogen-specific antibody detection kit(grant numbers 21S31901900);Shanghai"Rising Stars of Medical Talents"Youth Development Program(Youth Medical Talents-Clinical Laboratory Practitioner Program).

摘　　要：Antimicrobial resistance poses a significant threat to global public health,especially for Enterobacterales.In this study,we investigated the distribution and antimicrobial resistance of Enterobacterales in children in the China Antimicro-bial Surveillance Network(CHINET)in 2015-2021.In total,81,681 strains isolated from children were collected in this period,accounting for 50.1%of Gram-negative organisms.The most frequently isolated Enterobacterales were Escheri-chia coli,Klebsiella spp.,Salmonella spp.,and Enterobacter spp.The main sources of the isolates were urine and the res-piratory tract,accounting for 29.3%and 27.7%of isolates,respectively.The proportions of E.coli,Klebsiella pneumoniae,and Proteus mirabilis expressing extended-spectrumβ-lactamase were 48.8%-57.6%,49.3%-66.7%,and 23.1%-33.8%,respectively.The prevalence of carbapenem-resistant Enterobacterales was 5.7%-9.5%,which showed a decreasing trend from 2015 to 2021.The detection rates of carbapenem-resistant Klebsiella spp.,carbapenem-resistant Enterobac-ter spp.,and carbapenem-resistant E.coli were 14.1%-22.6%,7.1%-15.7%and 2.0%-3.4%,respectively.In Enterobac-terales,the resistance rates to ciprofloxacin were higher than to levofloxacin.However,the Enterobacterales strains were highly susceptible to amikacin,polymyxin B,and tigecycline.The resistance rate of Salmonella spp.to ampicillin was>70%,whereas their resistance rate to ceftriaxone was<30%.These findings indicate that the resistant rates of some Enterobacterales isolates in children to common antimicrobial agents show decreasing trends.Continu-ous monitoring of bacterial resistance should be strengthened to prevent and control the spread of drug-resistant bacteria.

关 键 词：CHILDREN Enterobacterales Bacterial resistance surveillance Extended-spectrumβ-lactamase Carbapenem-resistant Enterobacterales 

分 类 号：R37[医药卫生—病原生物学]