Trend of distribution and antimicrobial resistance in uropathogens in China from the CHINET antimicrobial resistance surveillance program,a 7-year retrospective study  

作　　者：Yanming Li Mingxiang Zou Qun Yan Jingzhong Liao Wenen Liu on behalf of the China Antimicrobial Surveillance Network(CHINET)Study Group 

机构地区：[1]Department of Clinical Laboratory,Xiangya Hospital,Central South University,Hunan Province,Changsha 410008,China [2]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Hunan Province,Changsha,China [3]不详

出　　处：《One Health Advances》2024年第1期182-191,共10页全健康进展(英文)

基　　金：funded by the China Antimicrobial Surveillance Network(independent medical grants from Pfizer,2020QD049);the Innovative R&D Project Subsidy Program of the Hunan Provincial Development and Reform Commission(Project No.2019875).

摘　　要：Urinary tract infections(UTIs)are common urological diseases that easily relapse and have led to an increasing eco-nomic and health burdens.The China Antimicrobial Surveillance Network(CHINET)system is one of the most influ-ential antimicrobial resistance surveillance networks in China.This study analyzed antimicrobial resistance and distri-bution trends of uropathogens from 2015 to 2021 using the CHINET system.A total of 261,893 non-duplicate strains were collected;Gram-positive bacteria accounted for 23.8%while Gram-negative bacteria accounted for 76.2%.Escherichia coli,Enterococcus faecium,Klebsiella pneumoniae,and Enterococcus faecalis were the most common species.The resistance to vancomycin,linezolid,and teicoplanin in E.faecalis and E.faecium was less than 3%.The prevalence of carbapenem-resistant strains of E.coli,K.pneumoniae,Pseudomonas aeruginosa,and Acinetobacter baumannii was 1.7%,18.5%,16.4%,and 40.3%,respectively.The prevalence of carbapenem-resistant A.baumannii increased from 27.6%in 2015 to 43.4%in 2021.The prevalence of methicillin-resistant Staphylococcus aureus decreased from 40.6%in 2015 to 22.9%in 2021.The resistance rates to mostβ-lactam antimicrobials,aminoglycosides and fluo-roquinolones in E.coli,K.pneumoniae,P.aeruginosa and A.baumannii isolated from ICU inpatients were significantly higher than in those isolated from outpatients and non-ICU inpatients.This study indicates that E.coli,Enterococcus,and K.pneumoniae were the most commonly isolated uropathogens in China.The bacterial species isolated and their antimicrobial resistance patterns differed in different patient populations.More attention must be paid uropath-ogen resistance surveillance to provide data for the rational use of antimicrobial agents.

关 键 词：Urine specimen Bacterial resistance surveillance Antimicrobial susceptibility testing Escherichia coli Multi-drug resistant bacteria 

分 类 号：R96[医药卫生—药理学]