KPNA2、snail、MMP-7在乳腺癌中的表达及临床病理意义  

Expression and Clinicopathological Significance of KPNA2,snail and MMP-7 in Breast Cancer

作　　者：魏丽丽 郝瑞卿 王华瑛 WEI Lili;HAO Ruiqing;WANG Huaying(Department of Pathology,Changyi Maternal and Child Health Hospital,Changyi 261300,Shandong,China;Department of Pediatrics,Changyi Maternal and Child Health Hospital,Changyi 261300,Shandong,China;Department of Gynecology,Changyi Maternal and Child Health Hospital,Changyi 261300,Shandong,China)

机构地区：[1]昌邑市妇幼保健院病理科,山东昌邑261300 [2]昌邑市妇幼保健院儿科,山东昌邑261300 [3]昌邑市妇幼保健院妇科,山东昌邑261300

出　　处：《医学信息》2025年第1期125-128,共4页Journal of Medical Information

基　　金：潍坊市卫生健康委科研项目(编号:WFWSJK-2023-296)。

摘　　要：目的探讨KPNA2、snail、MMP-7在乳腺癌中的表达状况及临床病理意义。方法选取昌邑市妇幼保健院2018年1月-2022年12月60例乳腺癌组织及其周围正常乳腺组织作为研究对象,采用免疫组织化学方法观察乳腺癌及正常乳腺组织中KPNA2、snail、MMP-7的表达情况,分析KPNA2、snail、MMP-7与乳腺癌常用临床病理参数的关系,并进一步分析三种蛋白在乳腺癌中表达的相关性。结果KPNA2、snail、MMP-7蛋白在乳腺癌组织中高表达,KPNA2、snail、MMP-7的表达与乳腺癌病理组织学分级、肿瘤大小、淋巴结转移、TNM分期、Ki-67指数相关(P<0.05),与ER、PR、HER-2的表达、年龄无关(P>0.05)。KPNA2表达与snail(r=0.314,P=0.007)、MMP-7(r=0.332,P=0.005)的表达呈正相关。结论KPNA2、snail、MMP-7在乳腺癌中高表达,与乳腺癌的组织分化及侵袭转移有关,KPNA2、snail、MMP-7作用于乳腺癌的发生发展,KPNA2表达与snail、MMP-7的表达有关,KPNA2在乳腺癌的发生发展与snail、MMP-7起协同作用。Objective To investigate the expression and clinicopathological significance of KPNA2,snail and MMP-7 in breast cancer.Methods From January 2018 to December 2022,60 cases of breast cancer tissues and their surrounding normal breast tissues in Changyi Maternal and Child Health Hospital were selected as the research objects.The expression of KPNA2,snail and MMP-7 in breast cancer and normal breast tissues was observed by immunohistochemistry.The relationship between KPNA2,snail,MMP-7 and common clinicopathological parameters of breast cancer was analyzed,and the correlation between the expression of three proteins in breast cancer was further analyzed.Results KPNA2,snail and MMP-7 protein were highly expressed in breast cancer tissues,and the expression of KPNA2,snail and MMP-7 was correlated with histopathological grade,tumor size,lymph node metastasis,TNM stage and Ki-67 index of breast cancer(P<0.05),but its was not related to the expression of ER,PR,HER-2 and age(P>0.05).The expression of KPNA2 was positively correlated with snail(r=0.314,P=0.007)and MMP-7(r=0.332,P=0.005).Conclusion KPNA2,snail and MMP-7 are highly expressed in breast cancer,which is related to the tissue differentiation,invasion and metastasis of breast cancer.KPNA2,snail and MMP-7 act on the occurrence and development of breast cancer.The expression of KPNA2 is related to the expression of snail and MMP-7.KPNA2 plays a synergistic role with snail and MMP-7 in the occurrence and development of breast cancer.

关 键 词：乳腺癌 KPNA2 SNAIL MMP-7 

分 类 号：R587.1[医药卫生—内分泌]