凝血四项联合血清胆碱酯酶水平检测对病毒性肝炎患者阳性检出率的影响  

Effect of Coagulation Four Indexes Combined with Serum Cholinesterase Level Detection on Positive Detection Rate of Patients with Viral Hepatitis

作　　者：曾丽红 李泉 孙楠 ZENG Lihong;LI Quan;SUN Nan(Department of Laboratory,Ningdu County Hospital of Traditional Chinese Medicine,Ningdu 342800,Jiangxi,China)

机构地区：[1]宁都县中医院检验科,江西宁都342800

出　　处：《医学信息》2025年第1期141-144,共4页Journal of Medical Information

摘　　要：目的探讨凝血四项联合血清胆碱酯酶水平检测对病毒性肝炎患者阳性检出率的影响。方法选取2022年9月-2023年6月在我院诊治的82例病毒性肝炎患者为研究对象并设为观察组,并选取同期在我院体检的健康者80例设为对照组,两者均进行凝血四项[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(Fbg)]、血清胆碱酯酶(CHE)检测,比较两组凝血四项指标水平,血清CHE水平,不同病情(急性肝炎、慢性肝炎、肝硬化、重型肝炎)患者凝血四项指标和血清CHE水平,并分析不同检测方法(凝血四项、血清CHE、凝血四项+血清CHE)对不同病情病毒性肝炎检出率。结果观察组Fbg、CHE均低于对照组,APTT、PT、TT均高于对照组(P<0.05);不同病情病毒性肝炎患者APTT、PT、TT、Fbg、CHE比较,差异有统计学意义(P<0.05),且APTT、PT、TT随病情严重不断升高,Fbg、CHE随病情严重不断下降(P<0.05)。凝血四项+血清CHE联合检测对不同病情患者检出率均高于凝血四项、血清CHE单独检测,且联合检测慢性肝炎、肝硬化检出率高于急性肝炎、重型肝炎(P<0.05)。结论凝血四项联合血清CHE水平检测可提高病毒性肝炎患者阳性检出率,并且可以对病情程度进行有效鉴别,尤其是慢性肝炎、肝硬化检出率较高,可作为临床诊断病毒性肝炎的重要指标。Objective To investigate the effect of coagulation four indexes combined with serum cholinesterase level detection on the positive detection rate of patients with viral hepatitis.Methods A total of 82 patients with viral hepatitis diagnosed and treated in our hospital from September 2022 to June 2023 were selected as the observation group,and 80 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.Both groups were tested for coagulation four indexes[activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen(Fbg)]and serum cholinesterase(CHE).The levels of coagulation four indexes and serum CHE between the two groups,and coagulation four indexes and serum CHE levels in patients with different conditions(acute hepatitis,chronic hepatitis,cirrhosis,severe hepatitis)were compared,and different detection methods(coagulation four indexes,serum CHE,coagulation four indexes+serum CHE)for different conditions of viral hepatitis detection rate were investigated.Results Fbg and CHE in the observation group were lower than those in the control group,APTT,PT and TT were higher than those in the control group(P<0.05).There were significant differences in APTT,PT,TT,Fbg and CHE among patients with viral hepatitis of different conditions(P<0.05),and APTT,PT and TT increased with the severity of the disease,while Fbg and CHE decreased with the severity of the disease(P<0.05).The detection rate of combined detection of coagulation four indexes and serum CHE in patients with different conditions was higher than that of coagulation four indexes and serum CHE alone,and the detection rate of combined detection of chronic hepatitis and cirrhosis was higher than that of acute hepatitis and severe hepatitis(P<0.05).Conclusion The detection of coagulation four indexes combined with serum CHE level can improve the positive detection rate of patients with viral hepatitis,and can effectively identify the severity of the disease,especiall

关 键 词：凝血四项 血清胆碱酯酶 病毒性肝炎 阳性检出率 

分 类 号：R512.6[医药卫生—内科学]