A cellular triad for linking cardiac niche to regeneration  

作　　者：Xiaokai Ma Junjie Hou Jing‑Wei Xiong 

机构地区：[1]Beijing Key Laboratory of Cardiometabolic Molecular Medicine,Institute of Molecular Medicine,and College of Future Technology,Peking University,Beijing 100871,China [2]School of Basic Medical Sciences,Institute of Biomedical Innovation,The Second Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330031,China

出　　处：《Cell Regeneration》2024年第1期55-57,共3页细胞再生(英文)

基　　金：National Key R&D Program of China(2023YFA1800600 and 2018YFA0800501);National Natural Science Foundation of China(32230032).

摘　　要：Cardiovascular disease is the leading cause of mortality with very limited therapeutic interventions,thus holding great hope for cardiac regenerative medicine.A recent work from Martin’s laboratory reports their identification of a fetal-like cardiomyocyte progenitor,adult cardiomyocyte type 2(aCM2),and its potential interactions withC3+cardiac fibroblasts andC3ar1+macrophages to form a regenerative cellular triad,which is only present in the regenerative heart models,YAP5SA-expressing adult hearts and neonatal hearts.The complement signaling is essential for cellular interactions in this regenerative triad.This Highlight summarizes these major findings and provides brief perspectives on the impact of this regenerative niche during cardiac regeneration in the future.

关 键 词：CARDIAC MORTALITY LINKING 

分 类 号：R54[医药卫生—心血管疾病]