Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons  

作　　者：Yangnan Hu Hao Wei Menghui Liao Shanying Han Xin Gao Yusong Wang Shan Zhou Dongyu Xu Xugang Zhuang Ye Yang Hong Cheng Bin Zhang Qingyue Cui Jieyu Qi Lei Tian Wenyan Li Xia Gao Renjie Chai 

机构地区：[1]State Key Laboratory of Digital Medical Engineering,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital,School of Life Sciences and Technology,Advanced Institute for Life and Health,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing,210096,China [2]Co-Innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China [3]Department of Otolaryngology Head and Neck Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Jiangsu Provincial Key Medical Discipline(Laboratory),Nanjing 210008,China [4]Department of Otolaryngology Head and Neck Surgery,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China [5]Department of Otolaryngology-Head and Neck Surgery,Shandong Provincial ENT Hospital,Shandong University,Jinan,Shandong,China [6]State Key Laboratory of Digital Medical Engineering,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital,School of Medicine,Advanced Institute for Life and Health,Southeast University,Nanjing,210096,China [7]ENT institute and Department of Otorhinolaryngology,Eye&ENT Hospital,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Fudan University,Shanghai,200031,China [8]Department of Neurology,Aerospace Center Hospital,School of Life Science,Beijing Institute of Technology,Beijing 100081,China [9]Institute for Stem Cell and Regeneration,Chinese Academy of Science,Beijing,China [10]Southeast University Shenzhen Research Institute,Shenzhen 518063,China

出　　处：《Engineered Regeneration》2024年第4期443-451,共9页再生工程(英文)

基　　金：supported by grants from National Key R&D Program of China(Nos.2020YFA0113600,2021YFA1101300,2021YFA1101800,2020YFA0112503);National Natural Science Foundation of China(Nos.82330033,82030029,92149304,82201292);Natural Science Foundation of Jiangsu Province(BK20232007);Jiangsu Provincial Scientific Research Center of Applied Mathematics(BK20233002);Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022);Open Project Fund of Guangdong Academy of Medical Sciences(YKY-KF202201);Beijing Natural Science Foundation(No.Z200019);China National Postdoctoral Program for Innovative Talent(BX20230070);China Postdoctoral Science Foundation(2023M740606);Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB597).

摘　　要：Cochlear implantation(CI)offers a dependable treatment for sensorineural hearing loss,with precision electroa-coustic stimulation parameters showing great potential in improving auditory outcomes in CI patients.Here,we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene’s excellent electrical conductivity and biocompatibility.Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron(SGN)neurites and growth cones,substantially boosting the calcium activity in SGNs.This study lays a theoretical foundation for the precision medicine approaches in CI patient care,and informs the selection of materials for cochlear implant electrode materials in the future.

关 键 词：Cochlear implant MXene Electroacoustic stimulation Cellular response 

分 类 号：R76[医药卫生—耳鼻咽喉科]