穴位贴敷联合调补脾肾法治疗多囊卵巢综合征患者的疗效及对其妊娠率的影响  

Efficacy of Acupoint Application Combined with Spleen-regulating and Kidney-tonifying Therapy on Treatment of Polycystic Ovary Syndrome and Its Impact on Pregnancy Rate

作　　者：刘博 张成奇[1] 董青 魏萱[1] 王娟[1] LIU Bo;ZHANG Cheng-qi;DONG Qing;WEI Xuan;WANG Juan(Department of Endocrinology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei 050000)

机构地区：[1]河北省石家庄市中医院内分泌科,河北石家庄050000

出　　处：《世界中西医结合杂志》2024年第12期2458-2462,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研项目计划(2019444)。

摘　　要：目的探讨穴位贴敷联合调补脾肾法治疗脾虚痰湿证多囊卵巢综合征(Polycystic ovary syndrome,PCOS)的临床疗效。方法选取2019年1月—2022年6月期间河北省石家庄市中医院收治的PCOS合并不孕症患者186例,采用随机数字表法分为对照组和治疗组,每组各93例。对照组患者采用调补脾肾法治疗,治疗组采用调补脾肾法联合穴位贴敷治疗。3个月为1个疗程,连续治疗3个疗程。观察比较两组患者临床疗效、安全性,治疗前后性激素水平[促卵泡生成素(Follicle stimulating hormone,FSH)、促黄体生成素(Luteinizing hormone,LH)、睾酮(Testosterone,T)]、糖脂代谢指标[空腹血糖水平(Fasting plasma glucose,FPG)、胰岛素水平、总胆固醇(Total cholesterol,TC)、甘油三酯(Triglyceride,TG)、胰岛素抵抗指数(Homeostatic model assessment of insulin resistance,HOMA-IR]、中医证候积分、卵巢体积、卵泡数目。结果治疗后治疗组临床总有效率95.70%(89/93)明显高于对照组88.17%(82/93),差异有统计学意义(P<0.05)。治疗后两组患者性激素FSH、LH、T水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组性激素水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者糖脂代谢指标FPG、HOMA-IR、TC、TG均较治疗前降低,差异有统计学意义(P<0.05);且治疗组糖脂代谢指标均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分较治疗前降低,差异有统计学意义(P<0.05);且治疗组中医证候积分低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者卵巢体积及卵泡数目均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者均未出现严重肝肾功能损伤、严重过敏反应等严重不良反应。结论穴位贴敷联合调补脾肾法治疗PCOS,可有效改善患者临床症状,调节患者性激素水平,纠正�Objective To explore the clinical efficacy of acupoint application combined with the spleen-regulating and kidney-tonifying therapy in the treatment of polycystic ovary syndrome(PCOS)with spleen deficiency and phlegm-dampness syndrome.Methods A total of 186 PCOS patients with infertility,admitted to Shijiazhuang Hospital of Traditional Chinese Medicine in Hebei Province from January 2019 to June 2022,were enrolled and randomly divided into a control group and a treatment group according to a random number table,with 93 cases in each group.The control group received spleen-regulating and kidney-tonifying therapy,while the treatment group received spleen-regulating and kidney-tonifying therapy combined with acupoint application.A course of treatment lasted for three months,and patients were treated for three consecutive courses.The clinical efficacy,safety,hormonal levels[follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T)],glycolipid metabolism indicators[fasting plasma glucose(FPG),insulin levels,total cholesterol(TC),triglyceride(TG),Homeostatic Model Assessment of Insulin Resistance(HOMA-IR)],traditional Chinese medicine(TCM)syndrome scores,ovarian volume,and follicle count were observed and compared between the two groups before and after treatment.Results After treatment,the clinical total effective rate in the treatment group was 95.70%(89/93),significantly higher than 88.17%(82/93)in the control group(P<0.05).After treatment,the levels of FSH,LH,and T were significantly lower in both groups than those before treatment(P<0.05),and the treatment group showed significantly lower hormone levels than the control group(P<0.05).After treatment,the glycolipid metabolism indicators FPG,HOMA-IR,TC,and TG in both groups were significantly lower than those before treatment(P<0.05),with the treatment group showing significantly lower indicators than the control group(P<0.05).After treatment,the TCM syndrome scores in both groups were significantly lower than those before treatment(P<0.05),and the t

关 键 词：多囊卵巢综合征 调补脾肾法 穴位贴敷 性激素 糖脂代谢紊乱 

分 类 号：R711.75[医药卫生—妇产科学]