百合知母汤对乳腺癌术后服用选择性雌激素受体调节剂引起心肺阴虚型血管舒缩症状患者的临床疗效观察  

Clinical Observation on the Effect of Baihe Zhimu Decoction on Vasomotor Symptoms Caused by Deficiency of Heart and Lung Yin Type of Selective Estrogen Receptor Modulators after Breast Cancer Surgery

作　　者：蒋可心 刘胜[1] 陈佳静 孙霃平[2] JIANG Ke-xin;LIU Sheng;CHEN Jia-jing;SUN Chen-ping(Shanghai University of Traditional Chinese Medicine,Shanghai 201203;Breast Department of Integrated Traditional Chinese and Western Medicine,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032)

机构地区：[1]上海中医药大学,上海201203 [2]上海中医药大学附属龙华医院中西医结合乳腺科,上海200032

出　　处：《世界中西医结合杂志》2024年第12期2502-2509,共8页World Journal of Integrated Traditional and Western Medicine

基　　金：上海市科学技术委员会基金项目(20Z21900300)。

摘　　要：目的探讨百合知母汤对乳腺癌术后服用选择性雌激素受体调节剂(Selective estrogen receptor modulators,SERMs)引起血管舒缩症状(Vasomotor symptoms,VMS)及其他身心症状的改善情况。方法选取2020年1月—2021年1月期间上海中医药大学附属龙华医院中西医结合乳腺科收治的乳腺癌术后患者62例,根据随机数字表法分为观察组和对照组,每组各31例。观察组口服百合知母汤联合乳癌术后方,对照组口服乳癌术后方,1剂/d,28剂为一疗程,共服用两个疗程。观察比较两组患者潮热积分、潮热频率、Greene更年期量表(Greene climacteric scale,GCS)、乳腺癌术后中医症状量表等疗效评价指标及安全性指标。结果治疗后观察组愈显率100.00%(31/31)明显高于对照组90.00%(27/30),差异有统计学意义(RR=3.200,95%CI:1.274-8.038,P<0.01)。治疗后两组患者潮热积分均较治疗前明显降低,差异有统计学意义(P<0.05,P<0.01);且观察组潮热积分明显低于对照组同期,差异有统计学意义(P<0.01)。治疗后两组患者GCS总积分、血管舒缩症状维度积分、焦虑症状维度积分、抑郁症状维度积分、躯体症状维度积分均较治疗前降低,差异有统计学意义(P<0.05,P<0.01);且观察组GCS总积分、血管舒缩症状维度积分、焦虑症状维度积分、抑郁症状维度积分、躯体症状维度积分均明显低于对照组,差异有统计学意义(P<0.05,P<0.01)。两组患者治疗前后性功能维度积分组间与组内比较,差异无统计学意义(P>0.05)。两组患者治疗后血管舒缩症状维度与其余各症状维度之间具有显著相关性,差异有统计学意义(P<0.01);除性功能外,焦虑症状、抑郁症状及躯体症状之间相关性亦显著,差异有统计学意义(P<0.01)。治疗后两组患者中医症状量表总分、躯体状况维度积分、心理状况维度积分均较治疗前明显降低,差异有统计学意义(P<0.05,P<0.01);且观察组中医症状量表总分及躯Objective To investigate the effect of Baihe Zhimu decoction on the improvement of vasomotor symptoms(VMS)and other physical and mental symptoms induced by selective estrogen receptor modulators(SERMs)after breast cancer surgery.Methods 62 breast cancer patients in the Breast Department of Integrated Traditional Chinese and Western Medicine,Longhua Hospital,Shanghai University of Traditional Chinese Medicine from January 2020 to January 2021 were selected.Meanwhile,these patients were divided into the observation group and control group according to the random number table method,with 31 cases in each group.The observation group took both Baihe Zhimu decoction and the postoperative breast cancer formula,while the control group took the postoperative breast cancer formula,with one dose per day,28 doses per course,and for two courses in total.The efficacy evaluation indexes and safety indexes such as the hot flash score,hot flash frequency,Greene Climacteric Scale(GCS),and traditional Chinese medicine symptom scale after breast cancer surgery were observed.Results After treatment,the cure rate of the observation group(100%)is significantly higher than that of the control group(90.00%),and the difference has statistical significance(RR=3.200,95%CI:1.274-8.038,P<0.01).Compared with the pre-treatment scores,the hot flash scores of the two groups significantly reduce after treatment,with differences of statistical significance(P<0.05,P<0.01).Additionally,the hot flash score of the observation group is notably lower than that of the control group over the same period,with differences of statistical significance(P<0.01).Compared with the scores before treatment,the GCS scores,score of VSM dimensions,score of anxiety symptom dimensions,score of depression symptom dimensions,and score of somatic symptom dimensions of both groups after treatment are significantly decreased,with differences of statistical significance(P<0.05,P<0.01).Additionally,all the above-mentioned scores of the observation group are remarkably lower tha

关 键 词：乳腺癌 雌激素受体调节剂 血管舒缩症状 百合知母汤 

分 类 号：R543[医药卫生—心血管疾病]