穴位贴敷治疗慢性持续期支气管哮喘的临床观察  

Clinical Observation on Acupoint Application in the Treatment of Chronic Persistent Bronchial Asthma

作　　者：金冠男 王馨[2] 崔相楠[2] 秦婷婷 江柏华 JIN Guannan;WANG Xin;CUI Xiangnan;QIN Tingting;JIANG Baihua(Department of Pulmonary Diseases,Heilongjiang Academy of Chinese Medicine Sciences,Harbin Heilongjiang 150046,China;Department of Pulmonary Diseases,Hanan Branch,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin Heilongjiang 150046,China)

机构地区：[1]黑龙江省中医药科学院肺病科,黑龙江哈尔滨150046 [2]黑龙江中医药大学附属第二医院哈南分院肺病科,黑龙江哈尔滨150046

出　　处：《中国卫生标准管理》2024年第24期151-155,共5页China Health Standard Management

基　　金：国家中医药管理局第七批全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号);黑龙江省中医药科研项目(ZHY2023-228)。

摘　　要：目的探讨穴位贴敷在肺肾气虚型慢性持续期支气管哮喘患者中的应用效果。方法选取黑龙江省中医药科学院2021年1月—2023年1月住院的50例肺肾气虚型慢性持续期支气管哮喘患者,以随机数字表法分为研究组和对照组,各25例。对照组在常规治疗基础上应用沙美特罗替卡松粉吸入剂,研究组在此基础上实施穴位贴敷治疗。治疗后对比2组患者的中医证候积分、肺功能及炎症因子等指标。结果治疗后研究组喘息、咳嗽、咳痰、肺部症状、舌象及总分为(0.34±0.11)分、(0.51±0.10)分、(0.41±0.09)分、(0.89±0.12)分(、0.16±0.03)分(、2.61±0.53)分,低于对照组的(1.03±0.15)分、(1.06±0.11)分、(1.04±0.12)分、(1.19±0.13)分、(0.99±0.12)分、(6.13±0.69)分,差异均有统计学意义(P<0.05)。治疗后,研究组白介素-4(interleukin-4,IL-4)、白介素-8(interleukin-8,IL-8)分别为(14.20±5.35)pg/mL、(13.22±2.78)pg/mL,低于对照组的(21.11±4.35)pg/mL、(22.15±3.48)pg/mL,差异均有统计学意义(P<0.05)。治疗后,研究组第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、最大呼气流量(peak expiratory flow,PEF)以及FEV1与用力肺活量(forcedvitalcapacity,FVC)的比值(FEV1/FVC)分别为(2.89±0.51)L、(2.93±0.43)L/s、(71.26±13.15)%,高于对照组的(2.06±0.31)L、(2.21±0.41)L/s、(62.15±13.05)%,差异均有统计学意义(P<0.05)。治疗后,研究组哮喘控制测试(asthma control test,ACT)为(21.63±5.61)分,高于对照组的(17.92±5.38)分;呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)为(21.68±5.34)ppb,低于对照组的(26.91±5.67)ppb,差异均有统计学意义(P<0.05)。结论对肺肾气虚型慢性持续期支气管哮喘患者实施穴位贴敷治疗能够有效改善临床症状、降低炎症水平、提高肺功能,有效控制哮喘发作。Objective To explore the therapeutic impact of acupoint cataplasm in chronic persistent bronchial asthma patients with deficient lung and kidney qi.Methods A total of 50 patients lung and kidney qi deficiency type chronic persistent bronchial asthma who were hospitalized at Heilongjiang Academy of Chinese Medicine Sciences from January 2021 to January 2023 were selected for the study.They were randomly divided into the study group and the control group,with 25 cases in each group using a random number table method.The control group received salmeterol and fluticasone powder inhalation on the basis of conventional treatment,while the study group received acupoint plaster therapy in addition to the conventional treatment.After treatment,the TCM syndrome scores,pulmonary function,and inflammatory markers of the two groups were compared.Results After treatment,the study group′s wheezing,coughing,sputum production,lung signs,tongue symptoms,and total score were(0.34±0.11)points,(0.51±0.10)points,(0.41±0.09)points,(0.89±0.12)points,(0.16±0.03)points,and(2.61±0.53)points,which were lower than(1.03±0.15)points,(1.06±0.11)points,(1.04±0.12)points,(1.19±0.13)points,(0.99±0.12)points,and(6.13±0.69)points of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-4(IL-4)and interleukin-8(IL-8)in the study group were(14.20±5.35)pg/mL and(13.22±2.78)pg/mL,respectively,which were lower than those in the control group(21.11±4.35)pg/mL and(22.15±3.48)pg/mL,respectively,the differences were statistically significant(P<0.05).After treatment,the forced expiratory volume in one second(FEV 1),peak expiratory flow(PEF),and the ratio of FEV1 to forced vital capacity(FVC)(FEV1/FVC)of the study group were(2.89±0.51)L,(2.93±0.43)L/s,and(71.26±13.15)%,respectively,which were higher than those of the control group(2.06±0.31)L,(2.21±0.41)L/s,and(62.15±13.05)%,the differences were statistically significant(P<0.05).After treatment,the asthma control test(ACT)of t

关 键 词：穴位贴敷 肺肾气虚型 慢性持续期支气管哮喘 中医外治 肺功能 炎症因子 

分 类 号：R256[医药卫生—中医内科学]