Lung-resident lymphocytes and their roles in respiratory infections and chronic respiratory diseases  

作　　者：Arka Sen Chaudhuri Jie Sun 

机构地区：[1]Beirne B.Carter Center for Immunology Research,University of Virginia,Charlottesville,VA 22908,USA [2]Division of Infectious Disease and International Health,Department of Medicine,University of Virginia,Charlottesville,VA 22908,USA

出　　处：《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第4期214-223,共10页呼吸与危重症医学(英文)

基　　金：supported by the US National Institutes of Health grants AI147394,AG069264,AI112844,HL170961,AI176171,and AI154598 to J.S.

摘　　要：Recent scientific breakthroughs have blurred traditional boundaries between innate and adaptive immunity,revealing a sophisticated network of tissue-resident cells that deliver immediate,localized immune responses.These lymphocytes not only provide rapid frontline defense but also present a paradoxical role in the pathogenesis of respiratory diseases such as asthma,chronic obstructive pulmonary disease,pulmonary fibrosis,and the long-term tissue consequences of viral infections including severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).This review traverses the intricate landscape of lung-resident lymphocytes,delving into their origins,diverse functions,and their dualistic impact on pulmonary health.We dissect their interactions with the microenvironment and the regulatory mechanisms guiding their activity,with an emphasis on their contribution to both immune protection and immunopathology.This review aims to elucidate the complex narrative of these cells,enhancing our understanding of the development of precise therapeutic strategies to combat acute and chronic pulmonary diseases.Through this exploration,the review aspires to shed light on the potential of harnessing lung-resident lymphocytes for the treatment of respiratory conditions.

关 键 词：Lung-resident lymphocytes Tissue-resident immunity Tissue-resident memory T cells Tissue-resident helper T cells Post-acute sequelae of SARS-CoV-2 Chronic obstructive pulmonary disease Asthma Pulmonary fibrosis 

分 类 号：R56[医药卫生—呼吸系统]