Advances in the awareness of tuberculosis-associated chronic obstructive pulmonary disease  

作　　者：Xiaoyan Gai Brian Allwood Yongchang Sun 

机构地区：[1]Department of Respiratory and Critical Care Medicine,Peking University Third Hospital,Center for Chronic Airway Diseases,Peking University Health Science Center,Peking University,Beijing 100191,China [2]Division of Pulmonology,Department of Medicine,Stellenbosch University&Tygerberg Academic Hospital,Cape Town 7505,South Africa

出　　处：《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第4期250-256,共7页呼吸与危重症医学(英文)

基　　金：supported by the National Natural Science Foundation of China(Nos.81400041,8217010845);Capital’s Funds for Health Improvement and Research(No.2022-2G-40910);Key Clinical Projects of Peking University Third Hospital(No.BYSYZD2022014);Peking University Medicine Fund of Fostering Young Scholars’Scientific&Technological Innovation(No.BMU2024YFJHPY014)supported by Fundamental Research Funds for the Central Universities.The funding bodies had no role in the design and writing of the manuscript。

摘　　要：Tuberculosis(TB)significantly increases the risk of developing chronic obstructive pulmonary disease(COPD),po-sitioning TB-associated COPD(TB-COPD)as a distinct category within the spectrum of respiratory diseases preva-lent,especially in low-and middle-income countries.This condition results from the body’s immune response to TB,leading to prolonged inflammation and consequent persistent lung damage.Diagnostic approaches,par-ticularly post-bronchodilator spirometry,are vital for identifying airflow obstruction and confirming TB-COPD.Furthermore,exploring potential biomarkers is crucial for a deeper insight into the pathogenesis of TB-COPD and the improvement of treatment strategies.Currently,this condition is primarily managed using inhaled bron-chodilators,with cautious use of inhaled corticosteroids advised owing to the increased risk of developing TB.This review delves into the epidemiology,clinical manifestations,pulmonary function,and imaging character-istics of TB-COPD,scrutinizing current and prospective biomarkers and therapeutic strategies.Furthermore,it underscores the necessity for focused research to bridge the knowledge and treatment gaps in this complex con-dition.

关 键 词：TUBERCULOSIS Chronic obstructive pulmonary disease Tuberculosis-associated chronic obstructive pulmonary disease Post-tuberculosis lung disease Lung function 

分 类 号：R56[医药卫生—呼吸系统]