When prenatal infection meets postnatal hyperoxia: Better models for bronchopulmonary dysplasia and its therapeutic approaches  

作　　者：Ying Dong Annika Leidner Manuela Marega Stefano Rivetti Saverio Bellusci 

机构地区：[1]Department of General Pediatrics and Neonatology,Justus-Liebig-University,Giessen 35392,Germany [2]Universities of Giessen and Marburg Lung Center,Cardio-Pulmonary Institute,Giessen 35392,Germany

出　　处：《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第4期289-292,共4页呼吸与危重症医学(英文)

基　　金：supported by research grants from the Else Kröner-Fresenius-Stiftung(No.2022_EKEA.43 to YD);supported by the JLU-CAREER Clinician Scientist Program。

摘　　要：To the editor,With increased survival of extremely preterm infants(EPIs)born at 22-28 weeks’gestational age(GA),bronchopulmonary dysplasia(BPD)has become one common and severe complication of EPI survivors.1 De-spite abundant clinical research,there is a lack of strategies to effectively prevent or treat BPD,and preclinical animal models are indispensable tools to elucidate BPD pathogenesis and seek potential pharmaceutical therapies.Here,we introduce a novel two-hit rodent model incorporat-ing both prenatal infection and postnatal hyperoxia which closely simu-lates BPD,providing an optimized preclinical platform for mechanistic and therapeutic research.

关 键 词：therapeutic DYSPLASIA INFECTION 

分 类 号：R72[医药卫生—儿科]