微纳电子器件在疾病微创诊断与治疗中的研究进展  

Advancements in micro-and nanoelectronic devices for minimally invasive disease diagnosis and treatment

作　　者：黄爽 陈家宜 黄新烁 贺梦怡 刘铮杰 姚传捷 徐兴元 刘静 蒋乐伦 陈惠琄 谢曦 Shuang Huang;Jiayi Chen;Xinshuo Huang;Mengyi He;Zhengjie Liu;Chuanjie Yao;Xingyuan Xu;Jing Liu;Lelun Jiang;Hui-Juan Chen;Xi Xie(Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument,School of Biomedical Engineering,Sun Yat-sen University,Shenzhen 518107,China;State Key Laboratory of Optoelectronic Materials and Technologies,Guangdong Province Key Laboratory of Display Material and Technology,School of Electronics and Information Technology,Sun Yat-sen University,Guangzhou 510006,China;The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]广东省传感技术和生物医学仪器重点实验室,中山大学生物医学工程学院,深圳518107 [2]光电材料与技术国家重点实验室,广东省显示材料与技术重点实验室,中山大学电子与信息工程学院,广州510006 [3]中山大学附属第一医院,广州510080

出　　处：《科学通报》2025年第2期205-222,共18页Chinese Science Bulletin

基　　金：国家重点研发计划(2021YFA0911100);国家自然科学基金(T2225010,32171399,32171456);中国博士后科学基金(2023T00386);广东省基础与应用基础研究基金(2023A1515011267,2023A1515111139);深圳市优秀科技创新人才培养(博士基础研究启动)项目(RCBS20231211090558093)资助。

摘　　要：随着微纳加工技术和新材料工艺的不断创新,应用于疾病诊断和治疗的电子器件呈现出小型化、柔性化和多功能化的发展趋势.在医学诊断和治疗领域,微创电子器件发挥着越来越重要的作用.微创诊断电子器件提供了靶向引导、手术监控和连续性诊断等功能,为组织病变的原位诊断提供了有效手段.微创治疗电子器件通过个性化调控的方式,为疾病治疗提供了多种选择,显著降低了患者的生理损伤和术后风险,提高了患者的康复速度.本文综述了应用于组织病变微创诊断与治疗的微纳电子器件的类型、特征及其设计思路,并从生化诊疗和物理诊疗技术的角度对其进行技术分析.最后,讨论了目前微纳电子器件在疾病微创诊断和治疗应用中面临的挑战与机遇.Recent advancements in micro-and nanofabrication,along with developments in materials science,are enabling the creation of miniaturized,flexible,and multifunctional electronic devices for disease diagnosis and treatment.Minimally invasive electronic devices are improving healthcare by providing more precise guidance,real-time surgical monitoring,and continuous assessment of tissue lesions during procedures.These devices offer the potential for more personalized treatment options,reducing patient trauma and promoting faster recovery.This review examines the design,functionality,and applications of micro-and nanoelectronic devices in minimally invasive procedures,with a focus on their biochemical and physical diagnostic capabilities.Progress in micro-nano fabrication has led to the development of devices that are increasingly integrated,adaptable,and versatile,making them promising tools in healthcare and biomedical engineering.The combination of these technologies supports the development of more accurate and personalized medical solutions,potentially enhancing the efficiency of diagnostics and treatment.However,there are still significant challenges that need to be addressed.High production costs,complex fabrication processes,low production yields,and device susceptibility to contamination present obstacles to widespread adoption.In addition,the precision and stability required for nanoscale fabrication in clinical settings add complexity to large-scale production.Issues related to device consistency,long-term reliability,power consumption,and heat dissipation also need to be resolved for successful integration into healthcare.Variations in device dimensions and material instability can affect performance,making effective encapsulation strategies essential for long-term reliability.To realize the full potential of micro-nanoelectronic devices in minimally invasive medicine,future research should focus on developing more cost-effective fabrication methods,improving nanoscale processing equipment,and advancing mult

关 键 词：微纳电子器件 微纳加工技术 可穿戴器件 微创技术 诊断与治疗 

分 类 号：R318[医药卫生—生物医学工程] TN03[医药卫生—基础医学]