肺结核患者血清微量元素对疾病发展与营养治疗影响的研究进展  

Research progress on serum trace elements in the development and nutritional support of pulmonary tuberculosis patients

作　　者：游成东 朱玲 李佩波 You Chengdong;Zhu Ling;Li Peibo(Department of Infectious Diseases,People’s Hospital of Xiushan County,Chongqing 409900,China;Department of Cardiovascular Diseases,People’s Hospital of Xiushan County,Chongqing 409900,China;Department of Tuberculosis Diseases,Chongqing Public Health Medical Center,Chongqing 403360,China)

机构地区：[1]重庆市秀山县人民医院感染科,重庆409900 [2]重庆市秀山县人民医院心血管内科,重庆409900 [3]重庆市公共卫生医疗救治中心结核科,重庆403360

出　　处：《中国防痨杂志》2025年第2期218-223,共6页Chinese Journal of Antituberculosis

基　　金：秀山县卫健委医学科研项目(2022XSKY19)。

摘　　要：血清微量元素水平的变化与疾病的活动性、治疗效果及患者的营养状态密切相关,肺结核患者常常存在蛋白质-能量型营养不良及必需微量元素的缺乏。微量元素的缺乏与肺结核之间存在明显的双向因果关系,即营养不良可能加剧肺结核的病情,而肺结核的存在又可能导致微量元素的进一步缺乏。笔者结合国内外结核病与微量元素的研究现状,对微量元素作用于结核分枝杆菌的机制、微量元素在肺结核患者中对于疾病诊断、病情严重程度评估、抗结核疗效和微量元素补充在营养治疗等方面的研究进展进行综述,以期增强对肺结核患者微量元素相关营养问题的认识水平和重视程度。Serum trace element concentrations are intrinsically linked to disease activity,treatment outcomes,and the nutritional status of patients.Pulmonary tuberculosis(PTB)patients frequently present with protein-energy malnutrition and deficiencies in essential micronutrients.A significant bidirectional relationship exists between micronutrient deficiencies and PTB:malnutrition can worsen the progression of PTB,while the disease itself further depletes micronutrient reserves.The author integrates current research on tuberculosis and trace elements,providing a comprehensive review of the mechanisms by which trace elements influence Mycobacterium tuberculosis.The review also examines the role of trace elements in diagnosing PTB,evaluating disease severity,enhancing the efficacy of anti-tuberculosis treatments,and their supplementation in nutritional therapy.This work aims to deepen understanding and raise awareness of trace element-related nutritional challenges in tuberculosis patients.

关 键 词：结核 肺 微量营养系 综述文献(主题) 

分 类 号：R52[医药卫生—内科学] R459.3[医药卫生—临床医学]