氧化应激在卵巢功能障碍中的作用机制研究进展  

Research on mechanisms of oxidative stress in ovarian dysfunction

作　　者：李媛[1] 张依莎 游典 童凯雯 项盈盈 陈怡辰 裴弈闻 张婷[1] LI Yuan;ZHANG Yisha;YOU Dian;TONG Kaiwen;XIANG Yingying;CHEN Yichen;PEI Yiwen;ZHANG Ting(Huzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases,Huzhou University,Huzhou 313000,China)

机构地区：[1]湖州师范学院湖州市重大慢性病精准防控重点实验室,浙江湖州313000

出　　处：《中国实验动物学报》2024年第12期1606-1615,共10页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家级大学生创新创业训练计划(202310347064)。

摘　　要：氧化应激(oxidative stress,OS)在年龄相关性卵巢衰老中起关键作用,其潜在机制复杂。近年来有研究表明氧化应激介导多种病理过程诱发衰老下的卵巢功能障碍,如线粒体功能障碍、慢性炎症、细胞凋亡以及端粒的缩短均在氧化应激导致的卵巢衰老中发挥作用,通过抗氧化治疗有助于改善氧化应激下的卵巢功能。Age-related ovarian aging is significantly influenced by oxidative stress,which has intricate underlying mechanisms.Studies conducted recently have demonstrated that oxidative stress is a mediator of several pathological processes that lead to ovarian dysfunction in aging.These processes include telomere shortening,chronic inflammation,apoptosis,and mitochondrial dysfunction.Under oxidative stress,antioxidant treatment can assist in enhancing ovarian function.

关 键 词：氧化应激 卵巢衰老 线粒体稳态 线粒体功能障碍 炎症微环境 细胞凋亡 染色体端粒 

分 类 号：Q95-33[生物学—动物学]