非酒精性脂肪性肝病动物模型制备及病证结合研究进展  

Research progress on the preparation of animal models of non-alcoholic fatty liver disease and combination of disease and syndrome

作　　者：马春霞 陈振东 田旭东[2] MA Chunxia;CHEN Zhendong;TIAN Xudong(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中医院,兰州730050

出　　处：《中国实验动物学报》2024年第12期1616-1625,共10页Acta Laboratorium Animalis Scientia Sinica

基　　金：甘肃省科技计划资助-青年科技基金项目(23JRRA1728);甘肃省教育厅高校教师创新基金项目(2023A-093);甘肃中医药大学科学研究与创新基金项目(2022KCYB-I0);甘肃省名中医传承工作室(国中医药规财函[2021]242号);甘肃中医药大学2024年大学生创新创业训练计划项目(S202410735030)。

摘　　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是指多种致病因素引起的,以脂肪在肝细胞内过度沉积为主要病变特征的代谢综合征。目前,NAFLD的发病机制尚未完全清楚,临床上缺乏针对NAFLD的特效药物。因此,建立理想动物模型在NAFLD发病机制的明确、特效药物研制及治疗方面显得极为重要。近五年来,除NAFLD动物模型被热议外,随着中医药事业的不断更新、发展,与NAFLD相关的病证结合模型也相继增多,现将近五年来常用的NAFLD动物模型及其制备和评价方法作一总结,以期为同道在今后NAFLD动物模型制备及病证结合研究方面提供参考。Non-alcoholic fatty liver disease(NAFLD)is a metabolic syndrome caused by a variety of pathogenic factors and characterized by the excessive deposition of fat in liver cells.At present,the pathogenesis of NAFLD is not fully understood,and there is a lack of specific drugs for NAFLD in clinical practice.Therefore,the establishment of an ideal animal model is extremely important for clarifying the pathogenesis of NAFLD and developing specific drugs and treatments.In addition to NAFLD animal models,an increasing number of disease-syndrome combined models related to NAFLD has emerged with the continuous renewal and development of traditional Chinese medicine over the past five years.This article summarizes the NAFLD animal models commonly used within the past five years,as well as their preparation and evaluation method,to provide a reference for future studies in NAFLD animal model preparation and modeling a combination of disease and syndrome.

关 键 词：非酒精性脂肪性肝病 动物模型 病证结合模型 模型评价 

分 类 号：Q95-33[生物学—动物学]