Immunity hubs orchestrating antiviral defense  

作　　者：Linnan Zhu Zemin Zhang 

机构地区：[1]Biomedical Pioneering Innovation Center(BIOPIC),and School of Life Sciences,Peking University,Beijing,China

出　　处：《Cell Research》2025年第1期7-8,共2页细胞研究(英文版)

摘　　要：Understanding the intricate dynamics of the immune response to SARS-CoV-2 is crucial for developing effective antiviral therapies.Two important studies published in Cell Discovery provide a detailed spatiotemporal map of the immune landscape in SARS-CoV-2-infected lungs,unveiling novel cellular hubs and their critical interplay with macrophages in orchestrating viral clearance and inflammation resolution.The immune response to SARS-CoV-2 is a multi-stage process involving immune surveillance,activation,tissue damage,viral clearance,and tissue repair.Identifying the key cell subpopulations and their regulatory networks at each stage is essential for deciphering COVID-19 pathogenesis and developing antiviral therapies.While previous studies have identified key cell types at various stages of infection,no single study has provided a comprehensive overview spanning the entire process,from infection to inflammation resolution.Additionally,the lack of high-resolution spatiotemporal data has hindered the visualization of in situ immune cell coordination,which is crucial for viral clearance and inflammation resolution.

关 键 词：INFLAMMATION INFECTION LANDSCAPE 

分 类 号：R392[医药卫生—免疫学]