Reducing functionally defective old HSCs alleviates agingrelated phenotypes in old recipient mice  

作　　者：Yuting Wang Wenhao Zhang Chao Zhang Hoang QTran Van Takashi Sein Yi Zhang 

机构地区：[1]Howard Hughes Medical Institute,Boston Children’s Hospital,Boston,MA,USA [2]Program in Cellular and Molecular Medicine,Boston Children’s Hospital,Boston,MA,USA [3]Division of Hematology/Oncology,Department of Pediatrics,Boston Children’s Hospital,Boston,MA,USA [4]Department of Genetics,Harvard Medical School,Boston,MA,USA [5]Harvard Stem Cell Institute,Boston,MA,USA.

出　　处：《Cell Research》2025年第1期45-58,共14页细胞研究(英文版)

摘　　要：Aging is a process accompanied by functional decline in tissues and organs with great social and medical consequences.Developing effective anti-aging strategies is of great significance.In this study,we demonstrated that transplantation of young hematopoietic stem cells(HSCs)into old mice can mitigate aging phenotypes,underscoring the crucial role of HSCs in the aging process.Through comprehensive molecular and functional analyses,we identified a subset of HSCs in aged mice that exhibit“younger”molecular profiles and functions,marked by low levels of CD150 expression.Mechanistically,CD150low HSCs from old mice but not their CD150high counterparts can effectively differentiate into downstream lineage cells.Notably,transplantation of old CD150low HSCs attenuates aging phenotypes and prolongs lifespan of elderly mice compared to those transplanted with unselected or CD150high HSCs.Importantly,reducing the dysfunctional CD150high HSCs can alleviate aging phenotypes in old recipient mice.Thus,our study demonstrates the presence of“younger”HSCs in old mice,and that aging-associated functional decline can be mitigated by reducing dysfunctional HSCs.

关 键 词：HSCS ORGANS aging 

分 类 号：R339.38[医药卫生—人体生理学]