Sequence-activated chemiluminescence probes:programmable illumination for high-contrast in vivo sensing and imaging  

作　　者：Yutao Zhang Juan Li Wei-Hong Zhu Zhiqian Guo 

机构地区：[1]Shanghai Key Laboratory of Functional Materials Chemistry,Joint International Research Laboratory of Precision Chemistry and Molecular Engineering,Institute of Fine Chemicals,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China [2]State Key Laboratory of Bioreactor Engineering,Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism,East China University of Science&Technology,Shanghai 200237,China

出　　处：《Science China Chemistry》2025年第1期26-34,共9页中国科学(化学英文版)

基　　金：supported by the National Key Research and Development Program of China(2023YFA1802000,2021YFA0910000);the National Natural Science Foundation of China(22225805,22308101,32394001,32121005);the Shanghai Science and Technology Innovation Action Plan(23J21901600);the Innovation Program of Shanghai Municipal Education Commission,China Postdoctoral Science Foundation(2021M701199)。

摘　　要：Sequence-activated chemiluminescence(CL)technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution.The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest,thus enabling high-contrast signals under complex physiological conditions.This sequential activation could be triggered by enzymes,reactive oxygen species(ROS),biothiols or changes in the microenvironment.These unique sequence-activated CL probes bestow several advantages,including minimal background,deep-tissue penetration,and the ability of non-invasive or minimally invasive detection.The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics.In this mini-review,we focus on the latest developments in sequential CL probes,addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关 键 词：chemiluminescnece sequence-activation in-vivo BIOIMAGING cyclic peroxide 

分 类 号：TN9[电子电信—信息与通信工程]