Enantioselective reductive conjugate alkenylation ofα,β-enones with keto alkenyl acetates by nickel catalysis  

作　　者：Rong-De He Yun-Lei Luo Qiu-Quan Pan Qi-Wei Yao Xing-Zhong Shu 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China

出　　处：《Science China Chemistry》2025年第1期157-162,共6页中国科学(化学英文版)

基　　金：supported by the National Natural Science Foundation of China(22271127,22071084);the Fundamental Research Funds for the Central Universities(lzujbky-2022-ey01)。

摘　　要：Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis,yet their asymmetric variant remains elusive.Concurrently,asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M.This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates.The method facilitates the enantioselective addition of keto alkenyl groups toα,β-enones,resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise.The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

关 键 词：nickel ALKENYLATION asymmetric CROSS-COUPLING ALKENES 

分 类 号：O62[理学—有机化学]