Intermolecular reductive coupling of aliphatic ketones with alkynes and alkenes by BCN photocatalysts  

作　　者：Yanping Xia Luyang Sun Jiajia Cheng Sibo Wang Meifang Zheng Xinchen Wang 

机构地区：[1]State Key Laboratory of Photocatalysis on Energy and Environment,College of Chemistry,Fuzhou University,Fuzhou 350116,China

出　　处：《Science China Chemistry》2025年第1期181-185,共5页中国科学(化学英文版)

基　　金：supported by the National Key Technologies R&D Program of China(2021YFA1502100);the National Natural Science Foundation of China(22071026,22372035,22072020,22302039,2247020090);the Science Foundation of the Fujian Province(2022HZ027004,2022L3082);the 111 Project(D16008)。

摘　　要：A photocatalytic process was developed for intermolecular reductive coupling of aliphatic ketones with alkynes/alkenes to furnish tertiary alcohols.Mechanistic studies support that boron carbonitrides(BCN)promote the single electron reduction of unactivated aliphatic ketones to generate ketyl radicals with visible light irradiation,which then react with alkynes and alkenes to afford the allylic and aliphatic alcohols,respectively.The heterogeneous photocatalytic system is compatible with diverse substrates including pharmaceutical-related molecules(43 examples)with reusability and scale-up experiments,verifying the complementary synthetic utility of this method to the homogeneous catalysts.

关 键 词：aliphatic ketones ketyl radical intermolecular cross-coupling tertiary alcohols 

分 类 号：O62[理学—有机化学]