Enantio-divergent C–H borylation with two different ligands from a single chiral source  

作　　者：Rongrong Du Senmiao Xu 

机构地区：[1]State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China [2]College of Material Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology,Ministry of Education,Hangzhou Normal University,Hangzhou 311121,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China Chemistry》2025年第1期226-232,共7页中国科学(化学英文版)

基　　金：supported by the National Key R&D Program of China(2022YFA1504302);the National Natural Science Foundation of China(92256302,22331011);the Natural Science Foundation of Jiangsu Province(BK20211092);the Major Program of the Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences(ZYFZFX-9);the Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences;the Hangzhou Normal University。

摘　　要：Reported here is an iridium-catalyzed enantio-divergent C(sp^(3))–H borylation ofα-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction.Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

关 键 词：asymmetric catalysis C–H borylation all-carbon quaternary stereocenters synthetic methods 

分 类 号：O62[理学—有机化学]