Alternatives to antibiotics in pig production:looking through the lens of immunophysiology  

作　　者：Hao-Yu Liu Chuyang Zhu Miaonan Zhu Long Yuan Shicheng Li Fang Gu Ping Hu Shihao Chen Demin Cai 

机构地区：[1]College of Animal Science and Technology,Yangzhou University,Yangzhou 225009,PR China [2]Joint International Research Laboratory of Agricultural&Agri-Product Safety,The Ministry of Education of China,Yangzhou University,Yangzhou,China

出　　处：《Stress Biology》2024年第1期806-828,共23页逆境生物学(英文)

基　　金：funded by the National Natural Science Foundation of China(32002243);the Natural Science Foundation of Jiangsu Province(BK20220582,BK20200932);the Jiangsu Agricultural Science And Technology Innovation Fund[CX(21)2014];the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).

摘　　要：In the livestock production system,the evolution of porcine gut microecology is consistent with the idea of“The Hygiene Hypothesis”in humans.I.e.,improved hygiene conditions,reduced exposure to environmental microorganisms in early life,and frequent use of antimicrobial drugs drive immune dysregulation.Meanwhile,the overuse of antibiotics as feed additives for infectious disease prevention and animal growth induces antimicrobial resistance genes in pathogens and spreads related environmental pollutants.It justifies our attempt to review alternatives to antibiotics that can support optimal growth and improve the immunophysiological state of pigs.In the current review,we first described porcine mucosal immunity,followed by discussions of gut microbiota dynamics during the critical weaning period and the impacts brought by antibiotics usage.Evidence of in-feed additives with immuno-modulatory properties highlighting probiotics,prebiotics,and phytobiotics and their cellular and molecular networking are summarized and reviewed.It may provide insights into the immune regulatory mechanisms of antibiotic alternatives and open new avenues for health management in pig production.

关 键 词：ANTIBIOTICS Gut-associated lymphoid tissues PROBIOTICS PREBIOTICS Phytobiotics The Hygiene Hypothesis 

分 类 号：F42[经济管理—产业经济]