中药冷溻联合1064 nm Q开关Nd∶YAG激光及透明质酸治疗玫瑰痤疮  

Application of Traditional Chinese Medicine Wet Compress Combined with 1064 nm Q-switched Nd∶YAG Laser and Hyaluronic Acid in Treating Rosacea

作　　者：李姗姗 王瑞丽 王晓云 王丽 LI Shanshan;WANG Ruili;WANG Xiaoyun;WANG Li(Department of Dermatology,Sunshine Union Hospital,Weifang 261000,Shandong,China)

机构地区：[1]山东阳光融和医院皮肤科,山东潍坊261000

出　　处：《中国美容医学》2025年第2期100-104,共5页Chinese Journal of Aesthetic Medicine

基　　金：潍坊市卫生健康委员会中医药科研项目(编号:WFZYY2023-4-003)。

摘　　要：目的:探究中药冷溻联合1064 nm Q开关Nd∶YAG激光及外涂透明质酸治疗玫瑰痤疮的临床效果。方法:选取2021年6月-2023年6月笔者医院收治的玫瑰痤疮患者129例,按随机数表法分为对照组(1064 nmQ开关Nd∶YAG激光及外涂透明质酸治疗)65例和治疗组(中药冷溻+1064 nm Q开关Nd∶YAG激光及外涂透明质酸治疗)64例,比较两组临床疗效、中医症状积分、持续性红斑评估量表(CEA)、丘疹脓疱评估量表(IGA)、皮肤病生活质量指数评分(DLQI)、皮肤屏障指标[经表皮水分流失率、角质层含水量、皮脂含量、pH值、乳酸刺激实验阳性率]、血清炎症指标[γ干扰素(IFN-γ)、肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、白介素17(IL-17)]和不良反应。结果:最终纳入对照组和治疗组各62例,共124例;治疗组总有效率为93.55%,高于对照组的80.65%(P<0.05);治疗12周后,治疗组各项中医症状积分低于对照组(P<0.05);治疗8、12周时,治疗组CEA、IGA、DLQI评分低于对照组(P<0.05);治疗8、12周时,治疗组经表皮水分流失率低于对照组(P<0.05),角质层含水量、皮脂含量、乳酸刺激实验阳性率高于对照组(P<0.05),治疗12周时,治疗组pH值低于对照组(P<0.05);治疗8、12周时,治疗组血清IFN-γ、TNF-α、IL-6、IL-17低于对照组(P<0.05);两组治疗期间均未发生不良反应。结论:中药冷溻联合1064 nm Q开关Nd∶YAG激光及外涂透明质酸治疗玫瑰痤疮的临床疗效较好,能显著改善患者症状和皮肤屏障功能,减轻炎症反应。Objective To evaluate the clinical efficacy of traditional Chinese medicine(TCM)wet compress combined with 1064 nm Q-switched Nd∶YAG laser and hyaluronic acid in the treatment of rosacea.Methods A total of 129 patients with rosacea admitted to the authors’hospital from June 2021 to June 2023 were randomly divided into a control group(n=65),receiving 1064 nm Q-switched Nd:YAG laser treatment and hyaluronic acid,and a treatment group(n=64),receiving TCM wet compress in addition to the same laser and hyaluronic acid therapy.Clinical efficacy,TCM symptom scores,continuous erythema assessment scale(CEA),Investigator Global Assessment(IGA)for papulopustular lesions,dermatology life quality index(DLQI),skin barrier indicators(transepidermal water loss,stratum corneum water content,sebum content,pH value,positive rate of lactic acid stimulation test),serum inflammatory markers[interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-17(IL-17)],and adverse reactions were compared between the two groups.Results A total of 124 patients completed the study,with 62 cases in each group.The total effective rate in the treatment group was 93.55%,significantly higher than 80.65%in the control group(P<0.05).After 12 weeks of treatment,TCM symptom scores were significantly lower in the treatment group than in the control group(P<0.05).At 8 and 12 weeks,CEA,IGA,and DLQI scores were significantly reduced in the treatment group compared to the control group(P<0.05).The transepidermal water loss rate was lower in the treatment group,while stratum corneum water content,sebum content,and the positive rate of the lactic acid stimulation test were higher(P<0.05).The pH value in the treatment group was lower than that in the control group at 12 weeks(P<0.05).Additionally,serum levels of IFN-γ,TNF-α,IL-6,and IL-17 were significantly lower in the treatment group at 8 and 12 weeks(P<0.05).No adverse reactions were observed in either group.Conclusion TCM wet compress combined with 1064 nm Q-switched Nd∶YAG

关 键 词：玫瑰痤疮 1064 nm Q开关Nd∶YAG激光 中药冷溻 透明质酸 皮肤屏障 炎症反应 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]