肽在增生性瘢痕防治中的应用进展  

Progress in the Application of Peptides in the Prevention and Treatment of Hypertrophic Scar

作　　者：张恩远(综述) 李景云 陈玲[1] 李俊(审校)[1] ZHANG Enyuan;LI Jingyun;CHEN Ling;LI Jun(Department of Plastic Surgery,Maternity Hospital Affiliated to Nanjing Medical University,Nanjing 210004,Jiangsu,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)整形外科,江苏南京210004

出　　处：《中国美容医学》2025年第2期176-179,共4页Chinese Journal of Aesthetic Medicine

基　　金：国家自然科学基金面上项目(编号:82072185)。

摘　　要：增生性瘢痕是由于皮肤组织过度纤维化而产生的病理性瘢痕,可引起功能性、社会心理学和美观上的问题。尽管目前的治疗方法有很多,但是现有的治疗手段疗效皆不确切,相关预防和治疗研究进展缓慢。近年来,越来越多的研究证据表明肽在增生性瘢痕防治方面具有重要作用。肽来源广泛,安全性高,易于制备;在促进创面愈合,抑制瘢痕增生,改善伤口预后等方面发挥着关键作用。本文主要从生长因子相关肽、肽类激素、神经肽、模拟肽、动物来源肽等方面就肽及其化合物在增生性瘢痕防治中的研究进展作一综述。Hypertrophic scar is a pathological scar caused by excessive fibrosis of skin tissue,which can cause functional,social psychological and aesthetic problems.Although there are many treatment methods at present,the efficacy of existing treatment methods is uncertain,and the related prevention and treatment research progress is slow.In recent years,more and more research evidence shows that peptide plays an important role in the prevention and treatment of hypertrophic scar.Peptides have wide sources,high safety,good stability and easy preparation.It plays a key role in promoting wound healing,inhibiting scar hyperplasia,improving wound prognosis.In this paper,the research progress of peptide and its compounds in the prevention and treatment of hypertrophic scar is reviewed from the aspects of growth factor related peptide,peptide hormone,neuropeptide,mimic peptide,animal derived peptide,etc.

关 键 词：增生性瘢痕 肽 创面愈合 纤维化 成纤维细胞 转化生长因子Β 

分 类 号：R619.6[医药卫生—外科学]