The Burden of Type 2 Diabetes in Adolescents and Young Adults in China:A Secondary Analysis from the Global Burden of Disease Study 2021  

作　　者：Junting Yang Siwei Deng Houyu Zhao Feng Sun Xiantong Zou Linong Ji Siyan Zhan 

机构地区：[1]Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China [2]Center for Intelligent Public Health,Institute for Artiffcial Intelligence,Peking University,Beijing 100871,China [3]Key Laboratory of Epidemiology of Major Diseases(Peking University),Ministry of Education,Beijing 100191,China [4]School of Medicine,Chongqing University,Chongqing 400030,China [5]The Department of Endocrinology and Metabolism,Peking University People’s Hospital,Beijing 100044,China [6]Research Center of Clinical Epidemiology,Peking University Third Hospital,Beijing 100191,China

出　　处：《Health Data Science》2024年第1期13-24,共12页健康数据科学(英文)

基　　金：supported by the National Natural Science Foundation of China(grant nos.82330107,72361127500,and 82204175).

摘　　要：Background:Early-onset type 2 diabetes(T2D)is an increasingly serious public health issue,particularly in China.This study aimed to analyze the characteristics of disease burden,secular trend,and attributable risk factors of early-onset T2D in China.Methods:Using data from the Global Burden of Disease(GBD)2021,we analyzed the age-standardized rate(ASR)of incidence,disability-adjusted life years(DALYs),and mortality rates of T2D among individuals aged 15 to 39 years in China from 1990 to 2021.Joinpoint regression analysis was employed to analyze secular trend,calculating the average annual percent change(AAPC).We also examined changes in the proportion of early-onset T2D within the total T2D burden and its attributable risk factors.Results:From 1990 to 2021,the ASR of incidence of early-onset T2D in China increased from 140.20[95%uncertainty interval(UI):89.14 to 204.74]to 315.97(95%UI:226.75 to 417.55)per 100,000,with an AAPC of 2.67%(95%CI:2.60%to 2.75%,P<0.001).DALYs rose from 116.29(95%UI:78.51 to 167.05)to 267.47(95%UI:171.08 to 387.38)per 100,000,with an AAPC of 2.75%(95%CI:2.64%to 2.87%,P<0.001).Mortality rates slightly decreased from 0.30(95%UI:0.24 to 0.38)to 0.28(95%UI:0.23 to 0.34)per 100,000,with an AAPC of−0.22%(95%CI:−0.33%to−0.11%,P<0.001).The 15 to 19 years age group showed the fastest increase in incidence(AAPC:4.08%,95%CI:3.93%to 4.29%,P<0.001).The burden was consistently higher and increased more rapidly among males compared to females.The proportion of early-onset T2D within the total T2D burden fluctuated but remained higher than global levels.In 2021,high body mass index(BMI)was the primary attributable risk factor for DALYs of early-onset T2D(59.85%,95%UI:33.54%to 76.65%),and its contribution increased substantially from 40.08%(95%UI:20.71%to 55.79%)in 1990,followed by ambient particulate matter pollution(14.77%,95%UI:8.24%to 21.24%)and diet high in red meat(9.33%,95%UI:−1.42%to 20.06%).Conclusion:The disease burden of early-onset T2D in China is rapidly increasing,particularly among

关 键 词：PREVENTION YOUNGER POLLUTION 

分 类 号：R58[医药卫生—内分泌]