Evaluation of albumin and lactate dehydrogenase in comparison with cytokeratin 19 fragments and neuronspecific enolase as diagnostic biomarkers for non-small cell lung cancer  

作　　者：Xiaodong Feng Ning Yuan Wei Xu Yingying Ji Xiaoyan Yu Zhijun Zhang 

机构地区：[1]Medical Research&Laboratory Diagnostic Center,Central Hospital Affiliated to Shandong First Medical University,Shandong Academy of Medical Sciences,Jinan,Shandong,China [2]Department of Clinical Laboratory,Fourth Teaching Hospital of Tianjin University of TCM,Tianjin,China [3]Department of Clinical Laboratory,Affiliated Tai'an City Central Hospital of Qingdao University,Tai'an,Shandong,China [4]Shandong Provincial Key Medical and Health Laboratory of Anti‐Drug Resistant Drug Research,Tai'an City Central Hospital,Tai'an,Shandong,China

出　　处：《iLABMED》2024年第4期227-237,共11页智能检验医学(英文)

基　　金：Natural Science Foundation of Shandong Province,Grant/Award Number:ZR2020QH283;National Natural Science Foundation of China,Grant/Award Number:82002226;Tai'an City Science and Technology Development Plan Project,Grant/Award Numbers:2022NS332,2022NS212;Nursery Project of the Affiliated Tai'an City Central Hospital of Qingdao University,Grant/Award Number:2022MPM01。

摘　　要：Background:The diagnosis of non-small cell lung cancer(NSCLC)is a clinical issue that requires attention,and more practical and effective biomarkers need to be selected to assist in diagnosis.This study aimed to examine the diagnostic value of serum albumin(ALB),lactate dehydrogenase(LDH),cytokeratin 19 fragments(CYFRA21-1),and neuron-specific enolase(NSE)for NSCLC.Methods:The clinical data of 1048 NSCLC patients and 1125 healthy subjects were extracted from electronic medical records.Receiver operating charac-teristic(ROC)curve analysis was performed to assess the diagnostic signifi-cance of ALB,LDH,CYFRA21-1,and NSE for NSCLC.The Cancer Genome Atlas(TCGA)data,which included mRNA profiles for ALB and LDH expression,were acquired from TCGA Program.Finally,interactive survival scatter plots and survival analyses for NSCLC patients were evaluated using the Human Protein Atlas and Kaplan-Meier Plotter.Results:Significant differences were noted in the levels of ALB and LDH be-tween NSCLC patients and healthy controls.The areas under the ROC curves(AUCs)for ALB and LDH were 0.754(95%CI:0.734-0.774)and 0.681(95%CI:0.658-0.704),respectively.Moreover,the combination of ALB and LDH raised the AUC to 0.804(95%CI:0.785-0.823),and the incorporation of CYFRA21-1 and NSE further increased the AUC to 0.903(95%CI:0.890-0.916).Notably,ALB and LDH might be related to the overall survival of NSCLC patients.Conclusion:This study revealed that ALB and LDH in NSCLC patient serum could improve the diagnostic accuracy of conventional biomarkers for NSCLC.

关 键 词：ALBUMIN biomarkers lactate dehydrogenase non-small cell lung cancer receiver operating characteristic 

分 类 号：R73[医药卫生—肿瘤]