Developing Rhodotorula as microbial cell factories for the production of lipids and carotenoids  

作　　者：Ting-Ting Zhang Ai-Hua Wu Muhammad Aslam Ji-Zhen Song Zhen-Ming Chi Guang-Lei Liu 

机构地区：[1]MOE Key Laboratory of Evolution and Marine Biodiversity,College of Marine Life Sciences,Ocean University of China,Yushan Road,No.5,Qingdao,Shandong 266003,China [2]Laboratory for Marine Biology and Biotechnology,Qingdao Marine Science and Technology Center,No.1 Wenhai Road,Qingdao 266237,China [3]Faculty of Basic Sciences,Bolan University of Medical and Health Sciences,Quetta 87600,Pakistan

出　　处：《Green Carbon》2024年第4期409-420,共12页绿碳(英文)

基　　金：supported by the Natural Science Foundation of Shandong Province(ZR2023YQ026 and ZR2022ZD24);the National Key R&D Program of China(2021YFC2103200);the National Natural Science Foundation of China(31970069).

摘　　要：Amid resource shortages and environmental concerns,microbial synthesis has emerged as a promising and sustainable alternative to traditional chemical synthesis.Rhodotorula,a genus of yeasts known for producing red pigments,has gained recognition for its ability to synthesize triglycerides,phospholipids,sterol esters,polyol esters of fatty acids,β-carotene,γ-carotene,torulene,and torularhodin.Rhodotorula has garnered increasing attention as a microbial cell factory,particularly for the production of valuable lipids and carotenoids.In this study,we review the research advancements and challenges associated with Rhodotorula,covering topics such as applicable carbon sources and their utilization mechanisms,key lipid and carotenoid products,and their metabolic pathways.We also provide an overview of the available gene manipulation techniques and associated challenges.Furthermore,this study emphasized the research significance of Rhodotorula based on recent developments and explored its potential as an alternative source of natural biological products.

关 键 词：RHODOTORULA LIPIDS Carotenoids Microbial cell factory Genetic manipulation 

分 类 号：O62[理学—有机化学]