替度格鲁肽在儿童短肠综合征应用2例  

Application of glucagon-like peptide-2 analogues in children with short bowel syndrome:a report of 2 cases

作　　者：陆丽娜[1] 冯海霞 黄柳芳 颜伟慧[1] 王莹[1,2] 蔡威 Lu Lina;Feng haixia;Huang Liufang;Yan Weihui;Wang Ying;Cai Wei(Department of Pediatric Gastroenterology and Nutrition,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai200092,China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,Shanghai200092,China;Shanghai Institute for Pediatric Medicine,Shanghai Institute of Pediatric Medicine,Shanghai200092,China)

机构地区：[1]上海交通大学医学院附属新华医院儿消化营养科,上海200092 [2]上海市小儿消化与营养重点实验室,上海200092 [3]上海市儿科医学研究所,上海200092

出　　处：《中华临床营养杂志》2024年第6期373-377,共5页Chinese Journal of Clinical Nutrition

摘　　要：短肠综合征(short bowel syndrome,SBS)患儿目前主要依赖长期肠外营养以获取充足的营养物质,直至小肠的长度和功能得到改善。近年来,人胰高血糖素样肽2类似物替度格鲁肽的临床应用使得SBS患者更有可能尽早脱离肠外营养,实现肠道功能自主。该文报道2例SBS患儿应用替度格鲁肽联合肠外和肠内营养进行肠康复治疗,最终脱离肠外营养的病例。据笔者查,国内尚未见儿科患儿使用替度格鲁肽的报道。Children with short bowel syndrome(SBS)mainly rely on long-term parenteral nutrition to obtain adequate nutrients until the length and function of the small intestine are improved.In recent years,the clinical application of human glucagon-like peptide 2 analogue Teduglutide has made it more likely for SBS patients to discontinue parenteral nutrition as early as possible and achieve intestinal functional autonomy.This paper reports two cases of SBS children who were treated with Teduglutide combined with parenteral and enteral nutrition for intestinal rehabilitation,and finally got rid of parenteral nutrition.According to the author,there have been no reports of pediatric children using Teduglutide in China.

关 键 词：短肠综合征 替度格鲁肽 GLP-2类似物 肠外营养 

分 类 号：R725.7[医药卫生—儿科]