小肠细菌过度生长与1型糖尿病的研究进展  

Research progress on small intestinal bacterial overgrowth and type 1 diabetes

作　　者：朱婷奕 李阳阳 刘煜 ZHU Tingyi;LI Yangyang;LIU Yu(Department of Endocrinology,Affiliated Sir Run Run Hospital,Nanjing Medical University,Nanjing,Jiangsu 211112,China)

机构地区：[1]南京医科大学附属逸夫医院内分泌科,南京211112

出　　处：《重庆医学》2025年第1期207-212,共6页Chongqing Medical Journal

基　　金：国家自然科学基金项目(82070849,82270871);国家重点研发计划项目(2022YFA0806103);江苏省南京市卫生科技发展专项资金项目(YKK22205)。

摘　　要：1型糖尿病(T1DM)是一种由于β细胞破坏、胰岛素绝对不足引起的自身免疫性糖尿病,受到遗传和环境因素的共同影响。近年来,肠道微生物作为调控宿主疾病和健康状况的重要组成部分受到广泛关注。小肠细菌过度生长(SIBO)是肠道微生物失调的一种类型,与T1DM有关。SIBO的存在可能加剧T1DM的发展,T1DM与SIBO的高发病率有着密切联系,然而,SIBO与T1DM之间的因果关系及其具体作用机制未能得到很好的阐明。该文综述了SIBO与T1DM的关系和相互作用,以及潜在的机制和干预措施,有助于发现T1DM的治疗新靶点、开发新的治疗方案。Type 1 diabetes mellitus(T1DM)is an autoimmune diabetes caused by the destruction ofβcells and insulin absolute insufficiency,which is influenced by a combination of genetic and environmental factors.In recent years,gut microbiota as an important part of regulating host disease and health status has received the extensive attention.Small intestinal bacterial overgrowth(SIBO)is a type of intestinal microbial dysbiosis that is associated with T1DM.The presence of SIBO may exacerbate the development of T1DM,which is closely associated with the high incidence of SIBO,however,the causal relationship between SIBO and T1DM and its specific mechanism of action are not well elucidated.This article reviews the relationship and interaction between SIBO and T1DM,and its potential mechanisms and interventional measures,which may help to discover the new therapeutic targets and develop the new treatment regimens for T1DM.

关 键 词：1型糖尿病 小肠细菌过度生长 机制 治疗 

分 类 号：R587.1[医药卫生—内分泌]