Cobalt-Catalyzed Regioselective Methylative Coupling of Internal Alkynes with Aldehydes/Aldimines  

作　　者：Jiwu Zhang Zhikun Liang Qinglei Chong Fanke Meng 

机构地区：[1]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,345 Lingling Road,Shanghai 200032,China [2]School of Chemistry and Materials Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,1 Sub-lane Xiangshan,Hangzhou,Zhejiang 310024,China [3]Beijing National Laboratory for Molecular Sciences,Beijing 100871,China

出　　处：《Chinese Journal of Chemistry》2024年第24期3248-3254,共7页中国化学(英文版)

基　　金：supported by the National Key R&D Program of China(2022YFA1506100);National Natural Science Foundation of China(Grant Nos.22371294,and 21821002);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0610000);Beijing National Laboratory for Molecular Sciences(BNLMS202304).

摘　　要：Catalytic methylative coupling of internal alkynes and aldehydes/aldimines through regioselective oxidative cyclization promoted by a phosphine–Co complex is presented.Such process constitutes an unprecedented and unique approach for Co-catalyzed generation of metallacycles that reversed inherent regiochemical biases to furnish a wide range of allylic alcohols and allylic amides bearing a tetrasubstituted alkene in up to 98%yield with high regioselectivity,representing a novel and general strategy for reversal of substrate-controlled regioselectivity in metal-catalyzed oxidative cyclization.

关 键 词：Cobalt Methylative coupling Alkynes Oxidative cyclization 3d transition metals Metallacycles Multicomponent reactions REGIOSELECTIVE 

分 类 号：O62[理学—有机化学]