Molecularly Imprinted Porous-Organic Framework with pH-Responsive Adsorption Sites for the Selective Adsorption of Iron  

作　　者：Yajie Yang Fuli Cai Cheng Zhang Nan Gao Suming Zhang Guangtong Wang Ye Yuan 

机构地区：[1]Key Laboratory of Automobile Materials of Ministry of Education & School of Materials Science and Engineering,Jilin University,Changchun,Jilin 130022,China [2]Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education,Northeast Normal University,Changchun,Jilin 130012,China [3]Beijing Key Laboratory of Energy Conversion and Storage Materials,College of Chemistry,Beijing Normal University,Beijing 100875,China [4]School of Medicine and Health,Harbin Institute of Technology,Harbin,Heilongjiang 150080,China

出　　处：《Chinese Journal of Chemistry》2024年第24期3324-3330,共7页中国化学(英文版)

基　　金：supported by the National Key R&D Program of China(Grant No.2022YFB3805902);the National Natural Science Foundation of China(Grant Nos.22322501,52204389,21975039,and 22077118);the Fundamental Research Funds for the Central Universities,Excellent Youth Team Program(grant No.2412023YQ001);the China Postdoctoral Science Foundation(2023T160261);the Finance Special Project on Medical and Health Talents of the Finance Department of Jilin Province(JLSWSRCZX2023-52);WBE Liver Fibrosis Foundation(No.2020009);Jilin Province Science and Technology Development Plan Project(YDZJ202401202ZYTS).

摘　　要：Regulating brain iron metabolism and reducing neuronal ferroptosis is proven to be a potential method for treating Alzheimer's disease(AD).However,gastric juice has a pH of 1.1—2.2 where a large number of interfering ions are dissociated from the food,which in turn causes traditional oral iron chelators to be saturated and inactivated.Herein,poly(4-vinylbenzoic acid)polymer chains were introduced as guided by Fe3+ion template into the porous network(TpPa-1)via molecularly imprinted technology to obtain porous iron chelators,[e-mail] COOH@TpPa-1 maintains a multiple hydrogen bonding structure to block the channels in the stomach(pH~1.1—2.2)with a strongly acidic environment,so just a small amount of active sites have been occupied.As COOH@TpPa-1 enters the colon,the alkaline environment disrupts the original hydrogen-bonded structure and forms anionic fragments,the bonding affinity for Fe^(3+)ions was~4.0 times that in the stomach,and also gave a high selective coefficient 4.2 times higher than that of conventional iron chelators.These designable"on"and"off"states promote the effective enrichment of iron ions within the colon by the porous chelator and produce a favorable therapeutic effect on Alzheimer's symptoms caused by ferroptosis in mice.

关 键 词：Alzheimer's disease Ferroptosis PH-RESPONSIVE Porous chelator Iron ion POLYANION Adsorption Hydrogen bonds 

分 类 号：O64[理学—物理化学]